Evidence map›Paper›PMID 39430768›Full record

ArticleFrontiers in immunology2024

Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation.

Anika Vear, Amlan Chakraborty, Farnaz Fahimi, Dorota Ferens, Robert Widdop, Chrishan S Samuel, Tracey Gaspari, Peter M van Endert, Siew Yeen Chai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anika VearDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Amlan ChakrabortyDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Farnaz FahimiDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Dorota FerensDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Robert WiddopDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Chrishan S SamuelDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Tracey GaspariDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Peter M van EndertInstitut Necker Enfants Malades, Université Paris Cité, INSERM, CNRS, Paris, France.
Siew Yeen ChaiDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a role in regulating the innate and adaptive immune response. There is a genetic association between IRAP and survival outcomes in patients with septic shock where a variant of its gene was found to be associated with increased 28-day mortality. This study investigated the role for IRAP in a lipopolysaccharide (LPS)-induced inflammatory response which is thought to model facets of the systemic inflammation observed in the early stages of human gram-negative sepsis. The frequencies and activation of splenic immune cell populations were investigated in the IRAP knockout (KO) mice compared to the wildtype controls over a period of 4-, 24-, or 48-hours following LPS stimulation. Dendritic cells isolated from the spleen of female IRAP KO mice, displayed significant increases in the activation markers CD40, CD86 and MHCII at 24 hours after LPS induction. A modest heightened pro-inflammatory response to LPS was observed with increased expression of activation marker CD40 in M1 macrophages from male IRAP knockout mice. Observations

Indexed as

Cystinyl AminopeptidaseDendritic CellsInflammationLipopolysaccharidesMacrophagesMice, KnockoutAnimalsFemaleMaleMiceMice, Inbred C57BLSex FactorsTime FactorsCystinyl Aminopeptidaseleucyl-cystinyl aminopeptidaseLipopolysaccharidesgram-negative sepsisinflammationinsulin regulated aminopeptidaseIRAPlipopolysaccharideLPS

Identifiers

PMID39430768
PMCPMC11486674

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.