Evidence map›Paper›PMID 39431640›Full record

ReviewAnnals of the New York Academy of Sciences2024

Disorders of puberty and neurodevelopment: A shared etiology?

Jordan E Read, Alexandru Vasile-Tudorache, Angel Newsome, María José Lorente, Carmen Agustín-Pavón, Sasha R Howard

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. GnRH and Cognition.Endocrinology · 2025
    Review
  7. Article
  8. Disorders of puberty and neurodevelopment: A shared etiology?Annals of the New York Academy of Sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan E ReadCentre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0001-6731-4440
Alexandru Vasile-TudoracheDepartment of Cell Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Valencia, Spain.
Angel NewsomeCentre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
María José LorenteDepartment of Cell Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Valencia, Spain.
Carmen Agustín-PavónDepartment of Cell Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Valencia, Spain.
Sasha R HowardCentre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-6698-903X

Funding

Barts Charity MGU0552FinRett 2022Wellcome TrustWellcome Trust 222049/Z/20/Z
6 · The paper itself

Abstract

The neuroendocrine control of puberty and reproduction is fascinatingly complex, with up- and down-regulation of key reproductive hormones during fetal, infantile, and later childhood periods that determine the correct function of the hypothalamic-pituitary-gonadal axis and the timing of puberty. Neuronal development is a vital element of these processes, and multiple conditions of disordered puberty and reproduction have their etiology in abnormal neuronal migration or function. Although there are numerous documented cases across multiple conditions wherein patients have both neurodevelopmental disorders and pubertal abnormalities, this has mostly been described ad hoc and the associations are not clearly documented. In this review, we aim to describe the overlap between these two groups of conditions and to increase awareness to ensure that puberty and reproductive function are carefully monitored in patients with neurodevelopmental conditions, and vice versa. Moreover, this commonality can be explored for clues about the disease mechanisms in these patient groups and provide new avenues for therapeutic interventions for affected individuals.

Indexed as

Neurodevelopmental DisordersPubertyFemaleHumansHypothalamo-Hypophyseal Systemautistic spectrum disorderdisordered pubertyhormone therapyneurodevelopmentprecocious puberty

Identifiers

PMID39431640
PMCPMC11580780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.