Evidence map›Paper›PMID 39433538›Full record

ArticleScientific reports2024

Biochemical markers and carotid intima-media thickness in relation to cardiovascular risk in young women.

Aleksandra Klisic, Jelena Kotur-Stevuljevic, Sanja Gluscevic, Serap Baydur Sahin, Filiz Mercantepe

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aleksandra KlisicUniversity of Montenegro-Faculty of Medicine, Podgorica, Montenegro. aleksandranklisic@gmail.com.
Jelena Kotur-StevuljevicDepartment for Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia.
Sanja GluscevicDepartment of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro.
Serap Baydur SahinGoztepe Medicalpark Hospital, Istanbul, Turkey.
Filiz MercantepeDepartment of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) is a major cause of death in the female population. The current study aimed to examine the relationship between CVD risk and novel endothelial dysfunction biomarkers [i.e., endocan, adiponectin and intercellular adhesion molecule (ICAM)-1] and carotid intima-media thickness (cIMT), respectively in a cohort of disease-free women of reproductive age. A total of 129 women were selected. Serum endocan, adiponectin and ICAM-1 were measured by a commercial enzyme-linked immunosorbent assay and cITM was determined by ultrasound. Cardiovascular risk score (CVRS) was calculated. The lowest endocan (p for trend = 0.051) and adiponectin (p for trend = 0.040) levels were found in a group of subjects with the highest CVRS. The cIMT values were the highest in second tertile subgroups, with the highest 75th percentile in a third tertile CVRS group, while the lowest cIMT values were detected in the lowest CVRS tertile group (p for trend = 0.001). A significant positive correlation between cIMT and CVRS (ρ = 0.307, p < 0.001), and a negative correlation between adiponectin and endocan with CVRS, respectively (ρ = - 0.252, p = 0.004; ρ = - 0.179, p = 0.043) were observed, but only endocan retained the independent association with CVRS (p = 0.030) in the multiple linear regression analysis. Endocan could be useful diagnostic tool in the estimation of cardiovascular risk in young women.

Indexed as

AdiponectinBiomarkersCardiovascular DiseasesCarotid Intima-Media ThicknessProteoglycansAdultFemaleHeart Disease Risk FactorsHumansIntercellular Adhesion Molecule-1Neoplasm ProteinsRisk FactorsYoung AdultAdiponectinBiomarkersESM1 protein, humanIntercellular Adhesion Molecule-1Neoplasm ProteinsProteoglycansBiomarkersCardiovascular riskInflammationInsulin resistanceObesity

Identifiers

PMID39433538
PMCPMC11494121

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.