Evidence map›Paper›PMID 39433541›Full record

ArticleCell discovery2024

NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout.

Jingwei Chi, Ying Chen, Changgui Li, Shiguo Liu, Kui Che, Zili Kong, Ziheng Guo, Yanchen Chu, Yajing Huang, Libo Yang and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Jingwei Chi *Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ying Chen *Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Changgui LiDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shiguo LiuDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Kui CheDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zili KongDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ziheng GuoDepartment of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yanchen ChuDepartment of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yajing HuangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Libo YangDepartment of Endocrinology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Cunwei SunDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yunyang WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wenshan LvDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Qing ZhangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Hui GuoDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Han ZhaoDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhitao YangDepartment of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Lili XuDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ping WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Bingzi DongDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jianxia HuDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shihai LiuMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Fei WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yanyun ZhaoDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Mengmeng QiDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yu XinDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Huiqi NanDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xiangzhong ZhaoMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wei ZhangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Min XiaoDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ke SiDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yangang WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. wangyg@qdu.edu.cn.
Yihai CaoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. yihai.cao@ki.se.ORCID http://orcid.org/0000-0003-1308-0065

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81870615Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) 2020MC065Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) 2021MH363
6 · The paper itself

Abstract

Defective renal excretion and increased production of uric acid engender hyperuricemia that predisposes to gout. However, molecular mechanisms underlying defective uric acid excretion remain largely unknown. Here, we report a rare genetic variant of gout-unprecedented NUMB gene within a hereditary human gout family, which was identified by an unbiased genome-wide sequencing approach. This dysfunctional missense variant within the conserved region of the NUMB gene (NUMB

Identifiers

PMID39433541
PMCPMC11494200

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.