Evidence map›Paper›PMID 39433760›Full record

ArticleNature communications2024

Developmental mouse brain common coordinate framework.

Fae N Kronman, Josephine K Liwang, Rebecca Betty, Daniel J Vanselow, Yuan-Ting Wu, Nicholas J Tustison, Ashwin Bhandiwad, Steffy B Manjila, Jennifer A Minteer, Donghui Shin and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026
    Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024
    Article
  20. Developmental encoding of natural sounds in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Fae N KronmanDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Josephine K LiwangDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Rebecca BettyDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Daniel J VanselowDepartment of Pathology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Yuan-Ting WuDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0002-8142-087X
Nicholas J TustisonDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-9418-5103
Ashwin BhandiwadAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6963-1594
Steffy B ManjilaDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0003-1069-6833
Jennifer A MinteerDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0001-6020-1996
Donghui ShinDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0009-0002-8926-5082
Choong Heon LeeBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.
Rohan PatilDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0009-0006-5435-3276
Jeffrey T DudaDepartment of Radiology, Penn Image Computing and Science Lab, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5031-5735
Jian XueDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0002-0969-6302
Yingxi LinDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0002-7002-1275
Keith C ChengDepartment of Pathology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Luis PuellesDepartment of Human Anatomy and Psychobiology, Faculty of Medicine, Universidad de Murcia, and Murcia Arrixaca Institute for Biomedical Research (IMIB), Murcia, Spain.
James C GeeDepartment of Radiology, Penn Image Computing and Science Lab, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jiangyang ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Yongsoo KimDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USA. yuk17@psu.edu.ORCID 0000-0002-4277-0279

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse BrainsRF1MH124605 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GEE, JAMES C, KIM, YONGSOO · 2020 to 2020
$3.8M
Understanding cellular architecture of the neurovascular unit and its function in the whole mouse brainR01NS108407 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$3.1M
Advanced Normalization ToolsR01EB031722 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2022 to 2025
$2.7M
Waxholm Space for Rodent NeuroinformaticsR01NS096720 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2016 to 2019
$2.4M
Brain-wide input and output wiring diagram of oxytocin neurons and its function in claustrum-endopiriform complexR01MH116176 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$2.4M
Medical Scientist Training ProgramT32GM149380 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERT LEVENSON · 2023 to 2026
$2.3M
Trophic Interactions of Nerve and MuscleR01AG031722 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWEATT, JOHN DAVID · 2007 to 2011
$1.6M
NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB031722NIGMS NIH HHS T32 GM149380NIMH NIH HHS R01 MH116176NIMH NIH HHS RF1 MH124605NINDS NIH HHS R01 NS096720NINDS NIH HHS R01 NS108407U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB031722U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH116176U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) RF1MH12460501U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS108407
6 · The paper itself

Abstract

3D brain atlases are key resources to understand the brain's spatial organization and promote interoperability across different studies. However, unlike the adult mouse brain, the lack of developing mouse brain 3D reference atlases hinders advancements in understanding brain development. Here, we present a 3D developmental common coordinate framework (DevCCF) spanning embryonic day (E)11.5, E13.5, E15.5, E18.5, and postnatal day (P)4, P14, and P56, featuring undistorted morphologically averaged atlas templates created from magnetic resonance imaging and co-registered high-resolution light sheet fluorescence microscopy templates. The DevCCF with 3D anatomical segmentations can be downloaded or explored via an interactive 3D web-visualizer. As a use case, we utilize the DevCCF to unveil GABAergic neuron emergence in embryonic brains. Moreover, we map the Allen CCFv3 and spatial transcriptome cell-type data to our stereotaxic P56 atlas. In summary, the DevCCF is an openly accessible resource for multi-study data integration to advance our understanding of brain development.

Indexed as

BrainImaging, Three-DimensionalMagnetic Resonance ImagingAnimalsAtlases as TopicFemaleGABAergic NeuronsMaleMiceMice, Inbred C57BLTranscriptome

Identifiers

PMID39433760
PMCPMC11494176

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.