Evidence map›Paper›PMID 39433769›Full record

ArticleNature communications2024

Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy.

Zachary Dewald, Oluwafolajimi Adesanya, Haneui Bae, Andrew Gupta, Jessica M Derham, Ullas V Chembazhi, Auinash Kalsotra

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Aberrant Splicing ofCirculation. Genomic and precision medicine · 2026
    Article
  4. Nuclear MBL-1 modulates mitochondrial morphology through carnitine palmitoyltransferase inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary DewaldDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Oluwafolajimi AdesanyaDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-8716-7457
Haneui BaeDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0000-9276-6326
Andrew GuptaDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Jessica M DerhamDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0004-6946-1275
Ullas V ChembazhiDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-6305-3156
Auinash KalsotraDepartment of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA. kalsotra@illinois.edu.ORCID 0000-0002-1011-0006

Funding

TNF ALPHA AND RECOVERY FROM ALCOHOLIC LIVER INJURYR01AA010154 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI ANNA MAE ELIZABETH DIEHL, Auinash Kalsotra · 1994 to 2026
$6.1M
Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Post-transcriptional mechanisms of gene regulation in cardiac cell growth and developmentR01HL126845 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KALSOTRA, AUINASH · 2015 to 2023
$3.5M
PHYSICAL EXERCISE, MENTAL ACTIVITY, AND BRAIN PLASTICITYR01AG010154 · NIA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GREENOUGH, WILLIAM T · 1991 to 2007
$1.5M
Gene Regulatory Mechanisms Controlling Tissue Maturation and PolyploidizationR21HD104039 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KALSOTRA, AUINASH · 2021 to 2022
$415k
Muscular Dystrophy Association (Muscular Dystrophy Association Inc.) MDA1072487NHLBI NIH HHS R01 HL126845NIAAA NIH HHS R01 AA010154NICHD NIH HHS R21 HD104039NIGMS NIH HHS T32 GM070421U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL126845U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R01AA010154
6 · The paper itself

Abstract

Myotonic Dystrophy type 1 (DM1), a highly prevalent form of muscular dystrophy, is caused by (CTG)

Indexed as

Disease Models, AnimalFatty LiverLiverMyotonic DystrophyAcetyl-CoA CarboxylaseAlternative SplicingAnimalsDiet, High-FatDNA-Binding ProteinsFemaleHepatocytesHumansMaleMiceMice, Inbred C57BLMice, TransgenicAcetyl-CoA CarboxylaseDMPK protein, mouseDNA-Binding ProteinsMbnl1 protein, mouseMyotonin-Protein KinaseRNA-Binding Proteins

Identifiers

PMID39433769
PMCPMC11494077

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.