ArticleNature genetics2024
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
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In one paragraph
Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.Journal of translational medicine · 2025Pooled it
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- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Shared Genetic Architecture Between Common Epilepsies and Subcortical Brain Volumes Is Associated With Cognition and Mental Health.CNS neuroscience & therapeutics · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.Translational psychiatry · 2026Article
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Mapping Focal and Generalized Effects of Common Genetic Variants on Human Brain Structure.bioRxiv : the preprint server for biology · 2026Article
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Relationships Between Polygenic Scores for Psychopathology and Observed Psychopathology Are Mediated by Cognitive Control and Reward Sensitivity Pathways: Insights From the ABCD Study.Biological psychiatry global open science · 2026Article
- Learning dynamics of unsupervised deep learning reveal epoch-specific genetic architectures of brain morphology.bioRxiv : the preprint server for biology · 2026Article
- Review
- A causal coding variant regulating alternative splicing ofScience advances · 2026Article
- Genetically inferred effects of brain structure and gene expression on neurodegenerative diseases: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Genome-wide analysis in over 1.6 million participants uncovers 147 loci associated with obstructive sleep apnoea.medRxiv : the preprint server for health sciences · 2025Article
- The overlapping genetic architecture of psychiatric disorders and cortical brain structure.Nature. Mental health · 2025Article
- Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.Human brain mapping · 2025Article
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Authors and funding
190 authors.
Luis M García-Marín *Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4731-6558
Adrian I Campos *Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Santiago Diaz-TorresSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-5442-9211
Jill A RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Zuriel CejaBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-2392-1964
Brittany L MitchellBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Katrina L GrasbyBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-8539-0228
Jackson G ThorpBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9461-6417
Ingrid AgartzDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Saud AlhusainiDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
David AmesAcademic Unit Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia.
Philippe AmouyelUniversite Lille, U1167-RID-AGE-LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging Diseases, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Ole A AndreassenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Konstantinos ArfanakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Alejandro Arias-VasquezDepartments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4786-0169
Nicola J ArmstrongDepartment of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0002-4477-293X
Lavinia AthanasiuCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Mark E BastinCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Alexa S BeiserDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Marco P M BoksBrain Center University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6163-7484
Dorret I BoomsmaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Rachel M BrouwerDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7466-1544
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Ralph BurkhardtInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg University, Regensburg, Germany.ORCID http://orcid.org/0000-0003-1924-1202
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-0482-8759
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS)-Georgia State, Georgia Tech and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9058-0747
Owen T CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, USA.
Mallar ChakravartyCerebral Imaging Centre, Douglas Research Centre, Montreal, Quebec, Canada.
Qiang ChenLieber Institute for Brain Development, Baltimore, MD, USA.
Christopher R K ChingLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sven CichonInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-9475-086X
Benedicto Crespo-FacorroHU Virgen del Rocio, Instituto de Investigacion Biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, Spain.ORCID http://orcid.org/0000-0003-0033-7132
Fabrice CrivelloCNRS, IMN, UMR 5293, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0001-6950-984X
Anders M DaleCenter for Multimodal Imaging and Genetics, La Jolla, CA, USA.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York City, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Greig I de ZubicaraySchool of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4506-0579
Stéphanie DebetteINSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Charles DeCarliImaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0003-1914-2693
Chantal DepondtDepartment of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium.
Sylvane DesrivièresSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Stefan EhrlichTranslational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Susanne ErkGerman Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway.
Guillén FernándezDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Irina FilippiINSERM U1299, Paris Saclay University, Gif-sur-Yvette, France.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Debra A FleischmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Evan FletcherDepartment of Neurology, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-9761-3131
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Andreas J ForstnerInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
Clyde FrancksDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-9098-890X
Barbara FrankeDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4785-4444
Aaron L GoldmanLieber Institute for Brain Development, Baltimore, MD, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Robert C GreenDepartment of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8472-0424
Oliver GrimmCentral Institute of Mental Health, Mannheim, Germany.
Nynke A GroenewoldDepartment of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-0865-8427
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Asta K HåbergDepartment of Neuromedicine and Movement, NTNU Science, Trondheim, Norway.
Unn K HaukvikNorwegian Centre for Mental Health Research (NORMENT), Department of Mental Health and Addiction, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0363-4127
Andreas HeinzGerman Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Derrek P HibarProduct Development, Genentech, Inc., South San Francisco, CA, USA.
Saima HilalSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore City, Singapore.
Jayandra J HimaliDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1391-9481
Beng-Choon HoDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-3976-1555
David F HoehnMax Planck Institute of Psychiatry, Munich, Germany.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1018-9954
Edith HoferDivision of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Wolfgang HoffmannGerman Centre for Neurodegenerative Diseases (DZNE)-Site Rostock/Greifswald, Greifswald, Germany.
Avram J HolmesDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-6583-803X
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-6839-0605
Norbert HostenDepartment of Radiology, University Clinic Greifswald, Greifswald, Germany.
M Kamran IkramDepartments of Epidemiology and Neurology, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0173-9571
Jonathan C IpserDepartment of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7916-622X
Neda JahanshadLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Erik G JönssonCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rene S KahnAltrecht Mental Health Institute, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-5909-8004
Ryota KanaiAraya, Inc, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0186-2687
Marieke KleinDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8784-5679
Maria J KnolDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3597-1531
Lenore J LaunerIntramural Research Program, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Stephen M LawrieDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2444-5675
Stephanie Le HellardDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-8085-051X
Phil H LeeCenter for Genomic Medicine, Mass General Brigham, Boston, MA, USA.
Hervé LemaîtreGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Université de Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0002-5952-076X
Shuo LiDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
David C M LiewaldPPLS, University of Edinburgh, Edinburgh, UK.
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
W T LongstrethDepartment of Neurology, University of Washington, Seattle, WA, USA.
Oscar L LopezDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-8546-8256
Michelle LucianoDepartment of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7306-3008
Pauline MaillardDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Andre F MarquandDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Nicholas G MartinBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Jean-Luc MartinotUniversité Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales Psychiatrie', Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Université Paris Cité, Centre Borelli, Gif sur Yvette, France.ORCID http://orcid.org/0000-0002-0136-0388
Karen A MatherCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Venkata S MattayLieber Institute for Brain Development, Baltimore, MD, USA.
Katie L McMahonSchool of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-6357-615X
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0003-0729-5246
Ingrid MelleCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9783-548X
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nazanin Mirza-SchreiberInstitute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-0836-8267
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3697-6617
Thomas H MosleyMIND Center, Jackson, MS, USA.
Thomas W MühleisenInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-6057-5952
Bertram Müller-MyhsokStatistics Genetics Group, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-0719-101X
Susana Muñoz ManiegaCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5185-6384
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Kwangsik NhoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Wiro J NiessenUniversity Medical Center Groningen, Groningen, The Netherlands.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Paul A NyquistDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jaap OosterlaanClinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0218-5630
Massimo PandolfoUniversité Libre de Bruxelles, Brussels, Belgium.
Tomas PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-1495-9338
Zdenka PausovaHospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-7784-1380
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7779-9672
G Bruce PikeDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-8924-683X
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Benno PützTranslational Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0002-2208-209X
Simone ReppermundCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Marcella D RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-3304-7943
Nina Romanczuk-SeiferthDepartment of Psychiatry and Neuroscience, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-6931-269X
Rafael Romero-GarciaDepartamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Sevilla, Spain.
Gennady V RoshchupkinDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3403-2313
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Philipp G SämannMax Planck Institute of Psychiatry, Munich, Germany.
Arvin SaremiLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0003-2395-8249
Muralidharan SargurupremrajINSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-1684-3750
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1376-8532
Lianne SchmaalCentre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Gottfried Schatz Center for Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria.ORCID http://orcid.org/0000-0001-9773-9992
Reinhold SchmidtDepartment of Neurology, Medical University Graz Austria, Graz, Austria.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Markus ScholzLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Gunter SchumannGerman Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.ORCID http://orcid.org/0000-0002-7740-6469
Emanuel SchwarzDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-0261-5063
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5443-0503
Jean ShinThe Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7353-5178
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334
Hilkka S SoininenDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Vidar M SteenDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Dan J SteinSAMRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Jason L SteinDepartment of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4829-0513
Sophia I ThomopoulosLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7902-3755
Diana Tordesillas-GutiérrezInstituto de Física de Cantabria (CSIC-UC), Santander, Spain.ORCID http://orcid.org/0000-0003-1458-3932
Julian N TrollorCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7685-2977
Maria C Valdes-HernandezCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Dennis van T EntDepartment of Biological Psychology and Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2001-1375
Hans van BokhovenDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-2153-9254
Dennis van der MeerCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Javier Vázquez-BourgonDepartment of Psychiatry, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.ORCID http://orcid.org/0000-0002-5478-3376
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0003-2604-2404
Louis N VinkeDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Joanna M WardlawCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9812-6642
Daniel R WeinbergerLieber Institute for Brain Development, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2409-2969
Michael W WeinerUniversity of California, San Francisco, San Francisco, CA, USA.
Wei WenCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2753-3870
Lars T WestlyeCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8644-956X
Eric WestmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-3115-2977
Tonya WhiteSection on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA.
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0001-9054-6688
Christiane WolfMax Planck Institute of Psychiatry, Munich, Germany.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3495-3710
Marcel P ZwiersDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Sudha SeshadriFramingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6135-2622
Paul M ThompsonLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Claudia L SatizabalFramingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Sarah E MedlandBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Miguel E RenteríaBrain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0003-4626-7248
Funding
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MMemory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9MHigh resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1MAssessing Alzheimer disease risk and heterogeneity using multimodal machine learning approachesU01AG068221 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DESTEFANO, ANITA L, LIN, HONGHUANG · 2021 to 2024
$2.5MComprehensive analysis of genetic pleiotropy in eleven neuropsychiatric disordersR01MH119243 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, PHIL H. · 2020 to 2024
$2.3MWorldwide Tractometry Initiative to Investigate Brain Microstructure, Cognitive Impairment & Dementia in Parkinsons DiseaseRF1NS136995 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, THOMPSON, PAUL M · 2024 to 2024
$2.2MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kNIA NIH HHS P30 AG010133NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIA NIH HHS U01 AG068221NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH119243NINDS NIH HHS RF1 NS136995
Abstract
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
Indexed as
BrainGenome-Wide Association StudyMultifactorial InheritanceAdultAttention Deficit Disorder with HyperactivityFemaleGenetic Predisposition to DiseaseGenomicsHumansMaleMiddle AgedOrgan SizeParkinson DiseasePolymorphism, Single NucleotideWhite People
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.