ArticleBMC neurology2024
Deep medullary vein abnormalities impact white matter hyperintensity volume through increases in interstitial free water.
Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Deep medullary veins score is associated with idiopathic normal pressure hydrocephalus in patients with arteriolosclerotic cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Deep medullary vein dysfunction is associated with cerebral microbleeds in cerebral small vessel disease.Frontiers in human neuroscience · 2025Article
- Enlarged perivascular spaces in the basal ganglia region are associated with white matter interstitial fluid content via deep medullary vein dysfunction.Frontiers in human neuroscience · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundOur intent was to explore the mediating role of interstitial free water (FW) linking deep medullary vein (DMV) score to white matter hyperintensity (WMH) volume.
methodsOur research team conducted a forward-looking analysis of initial clinical and imaging information gathered from 125 patients with cerebral small vessel disease. We identified six anatomic DMV regions on susceptibility weighted imaging (SWI) studies. Each region earned a score of 0-3, determined by the visual conditions of vessels, summing all six to generate a DMV score. We utilized fluid-attenuated inversion recovery (FLAIR) sequences to measure the volume of WMH. Additionally, we employed diffusion tensor imaging (DTI) to assess FW value.
resultsDMV score significantly positively correlated with FW value and with WMH volume (p < 0.05), and value of FW positively correlated with WMH volume (p < 0.05). The indirect effect of DMV score on WMH volume was mediated by FW (β = 0.281, 95% confidence interval [CI]: 0.178-0.388), whether adjusted for age and gender (β = 0.142, 95% CI: 0.058-0.240) or for age, gender and vascular risk factors (β = 0.141, 95% CI: 0.054-0.249).
conclusionDMV score correlate with WMH volume by virtue of FW increases in white matter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.