Evidence map›Paper›PMID 39435143›Full record

ArticleiScience2024

Development of a non-invasive bioassay for adiponectin target engagement in mice.

Jialing Tang, Yubin Lei, Angelica Pignalosa, Henry H Hsu, Ali A Abdul-Sater, Gary Sweeney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jialing TangDepartment of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
Yubin LeiDepartment of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
Angelica PignalosaAllysta Pharmaceuticals Inc., 500 108th Avenue NE, Suite 1100, Bellevue, WA 98004, USA.
Henry H HsuAllysta Pharmaceuticals Inc., 500 108th Avenue NE, Suite 1100, Bellevue, WA 98004, USA.
Ali A Abdul-SaterSchool of Kinesiology and Health Science, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
Gary SweeneyDepartment of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin-based therapeutic strategies are promising for managing metabolic diseases and reducing inflammation, prompting the development of adiponectin receptor agonists. However, monitoring their pharmacodynamic actions in clinical applications is challenging. This study aimed to identify peripheral biomarkers to monitor adiponectin actions using ALY688, an adiponectin receptor agonist peptide. RNA sequencing analysis of whole blood identified a cluster of genes that were significantly increased in the ALY688-treated group compared to the control. This gene cluster was validated by qPCR and further confirmed in human peripheral blood mononuclear cells treated with ALY688

Indexed as

Cell biologyGeneticsHuman metabolism

Identifiers

PMID39435143
PMCPMC11492082

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.