Evidence map›Paper›PMID 39435372›Full record

ArticleMaterials today. Bio2024

One arrow two eagles: Multifunctional nano-system for macrophage reprogramming and osteoclastogenesis inhibition against inflammatory osteolysis.

Tong Sha, Ze Wang, Jinwei Li, Yahong Wu, Jinbiao Qiang, Zhenming Yang, Yue Hu, Kaijuan Zheng, Shuyu Zhang, Haizhu Sun and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tong ShaDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Ze WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Jinwei LiDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Yahong WuDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Jinbiao QiangDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Zhenming YangDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Yue HuSchool and Hospital of Stomatology, China Medical University, Shenyang, PR China.
Kaijuan ZhengDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Shuyu ZhangDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Haizhu SunKey Laboratory of Sustained and Advanced Functional Materials, College of Chemistry, Northeast Normal University, Changchun 130024, PR China.
Andrew K WhittakerAustralian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia.
Bai YangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Hongchen SunDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.
Quan LinState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Ce ShiDepartment of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun, 130021, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory osteolysis poses a significant worldwide threat to public health. However, current monotherapies, which target either the prevention of the inflammatory response or the attenuation of osteoclast (OC) formation, have limited efficacy due to the complexity of the bone immune system being overlooked. Herein, by means of modifying salmon calcitonin (sCT), a multifunctional nano-system (AuNDs-sCT) was designed to synergistically inhibit OC differentiation and reverse the inflammatory microenvironment against inflammatory osteolysis. On the one hand, AuNDs-sCT effectively restrained OC differentiation by binding to the calcitonin receptors on the surface of OC precursors, resulting in the down-regulation of OC-specific genes and proteins. The targeted capacity of AuNDs-sCT provided a more durable and precise therapeutic effect. On the other hand, AuNDs-sCT exhibited antioxidant and anti-inflammatory effects, which regulated the polarization "switch" from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype in macrophages by the inhibition of NF-κB p65 phosphorylation, thereby effectively reversed the local inflammatory microenvironment. Additionally, AuNDs-sCT served as a promising fluorescent probe, enabling real-time visualization of the therapeutic process. This capability is expected to optimize drug administration and evaluate therapeutic effects. In summary, by inhibiting OC differentiation and reprogramming macrophages, AuNDs-sCT successfully realized drug repurposing and achieved the "one arrow two eagles" therapeutic strategy, which offers a synergistic and effective treatment option for the clinical management of inflammatory osteolysis.

Indexed as

Drug repurposingInflammatory microenvironmentInflammatory osteolysisMacrophage reprogrammingOsteoclastogenesis inhibition

Identifiers

PMID39435372
PMCPMC11492609

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.