ArticleInsights into imaging2024
Reproducibility of ultrasound-derived fat fraction in measuring hepatic steatosis.
Article in Insights into imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ultrasound-derived fat fraction for diagnosing hepatic steatosis: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Diagnostic performance of ultrasound-derived fat fraction for grading hepatic steatosis in patients with chronic liver diseases: a multicenter study.European radiology · 2026Article
- Impact of acquisition geometry on ultrasound-derived fat fraction measurements: implications for standardized acquisition and measurement interchangeability.Quantitative imaging in medicine and surgery · 2026Article
- Quantitative liver ultrasound: current status and challenges.Ultrasonography (Seoul, Korea) · 2026Article
- Quantitative ultrasound-derived fat fraction for hepatic steatosis in MASLD using liver biopsy as the reference standard: a dual-center study.European radiology · 2026Article
- Non-invasive imaging diagnostic techniques in metabolic dysfunction-associated steatotic liver disease: a roadmap for clinicians.Hormones (Athens, Greece) · 2026Review
- Accurate and spatially stable quantification of hepatic steatosis using ultrasound-derived fat fraction in metabolic dysfunction-associated steatotic liver disease (MASLD): a prospective magnetic resonance imaging-proton density fat fraction (MRI-PDFF) study.Quantitative imaging in medicine and surgery · 2026Article
- Comparison of ultrasound-derived fat fraction and hepatorenal index for quantitative detection of hepatic steatosis: a multicenter MRI-PDFF-referenced study.Frontiers in nutrition · 2026Article
- Quantitative ultrasound-derived fat fraction for identifying pediatric patients with metabolic dysfunction-associated steatotic liver disease: a prospective study.Pediatric radiology · 2025Article
- Ultrasound-derived fat fraction for the noninvasive quantification of hepatic steatosis: a prospective multicenter study.Insights into imaging · 2025Article
- Quantitative Ultrasound for Hepatic Steatosis: A Systematic Review Highlighting the Diagnostic Performance of Ultrasound-Derived Fat Fraction.Diagnostics (Basel, Switzerland) · 2025Review
- Ultrasound derived fat fraction indicates reduction of liver fat content after lifestyle modification in obese patients.Clinical hemorheology and microcirculation · 2025Article
- Quantifying changes in steatotic liver disease after bariatric surgery using ultrasound-derived fat fraction.Radiology advances · 2025Article
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7 authors.
Funding
Abstract
purposeSteatotic liver disease (SLD) has become the most common cause of chronic liver disease. Nevertheless, the non-invasive quantitative diagnosis of steatosis is still lacking in clinical practice. This study aimed to evaluate the reproducibility of the new parameter for steatosis quantification named ultrasound-derived fat fraction (UDFF). MATERIALS AND
methodsThe UDFF values were independently executed by two operators in two periods. In the process, repeated measurements of the same patient were performed by the same operator under different conditions (liver segments, respiration, positions, and dietary). Finally, the results of some subjects (28) were compared with the MRI-derived proton density fat fraction (PDFF). The concordance analysis was mainly achieved by the intraclass correlation coefficient (ICC) and Bland-Altman.
resultsOne hundred-five participants were included in the study. UDFF had good reliability in measuring the adult liver (ICC
conclusionUDFF measurements had good reproducibility. Furthermore, the state of S8, end-expiration, supine, and fasting might be the more stable measurement approach. CRITICAL RELEVANCE STATEMENT: UDFF is the quantitative ultrasound parameter of hepatic steatosis and has good reproducibility. It can show more robust performance under specific measurement conditions (S8, end-expiratory, supine, and fasting).
trial registrationThe research protocol was registered at the Chinese Clinical Trial Registry on October 9, 2023 ( http://www.chictr.org.cn/ ). The registration number is ChiCTR 2300076457. KEY POINTS: There is a lack of non-invasive quantitative measurement options for hepatic steatosis. UDFF demonstrated excellent reproducibility in measuring hepatic steatosis. S8, end-expiratory, supine, and fasting may be the more stable measuring condition. Training could improve the operators' measurement stability. Variable measurement state affects the repeatability of the UDFF values (Cov).
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