ArticleESC heart failure2025
Urine chloride trajectory and relationship with diuretic response in acute heart failure.
Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Urine sodium-guided diuresis in acute heart failure: a systematic review and meta-analysis of efficacy and safety.Heart failure reviews · 2025Pooled it
- The 'Chloride Theory' for Heart Failure Pathophysiology: An Updated Narrative Review 2025.Cardiology and therapy · 2026Review
- Urinary potassium/urinary creatinine ratio in outpatients with heart failure: factors associated and prognostic implications.Scientific reports · 2026Article
- Reported decision-making regarding diuretic use and urinary sodium monitoring in acute heart failure: a vignette-based survey in three European countries.ESC heart failure · 2026Article
- Hyponatraemia in heart failure: a mechanistic approach to contemporary management.Heart failure reviews · 2026Review
- Early arterial lactate trajectories and mortality risk in critically ill heart failure: a two-cohort trajectory analysis.Scientific reports · 2025Article
- The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization.ESC heart failure · 2025Article
- Dynamics of urinary chloride and sodium and their link to decongestion in acute heart failure and preserved ejection fraction: NACLOCRo-HF study.ESC heart failure · 2025Article
- Urinary markers in heart failure - types, timing and thresholds. European Journal of Heart Failure expert consensus document.European journal of heart failure · 2025Review
- The Role of Chloride in Cardiorenal Syndrome: A Practical Review.Journal of clinical medicine · 2025Review
- Chloride dipstick to rapidly estimate urine sodium during diuresis in acute heart failure.Pharmacotherapy · 2025Article
- Urine chloride trajectory and relationship with diuretic response in acute heart failure.ESC heart failure · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
aimsSodium excretion is a well-defined marker used to assess diuretic response in acute heart failure (AHF). Despite a strong pathophysiological background, the role of urine chloride excretion has not been described and established yet. We aimed to evaluate chloride trajectory during intensive diuretic treatment in AHF patients and examine its potential role in predicting poor diuretic response.
methodsThe study was conducted on 50 AHF patients. Participants were included within the first 36 h of hospitalization. They received furosemide dose adjusted for body weight (half in bolus, half in 2 h infusion). Post-diuretic hourly urine collection with biochemical analysis was performed.
resultsIn general, the concentrations of urine chloride (uCl
conclusionsUrine chloride and sodium are highly interrelated during decongestion of AHF patients. The uCl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.