Sex differences in the association of overweight with cognitive performance in individuals with first-episode psychosis.

Martí Llaurador-Coll, Ángel Cabezas, M José Algora, Montse Solé, Elisabet Vilella, Vanessa Sánchez-Gistau

Abstract read

In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Martí Llaurador-CollHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain.ORCID http://orcid.org/0000-0001-7095-7041

Ángel CabezasHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain.

M José AlgoraHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain.

Montse SoléHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain.

Elisabet VilellaHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain.ORCID http://orcid.org/0000-0002-1887-5919

Vanessa Sánchez-GistauHospital Universitari Institut Pere Mata (HU-IPM), Ctra de l'Institut Pere Mata, s/n, 43206, Reus, Spain. sanchezv@peremata.com.

Funding

WOMEN AND AGING--WELL BEING IN LATE LIFER55AG017357 · NIA · WAYNE STATE UNIVERSITY · PI LYSACK, CATHERINE L · 1999 to 1999

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Generalitat de Catalunya (Government of Catalonia) 2017SGR-00444Generalitat de Catalunya (Government of Catalonia) 2021SGR-01065Generalitat de Catalunya (Government of Catalonia) SLT006/17/357Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI18/00514Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI21/00612Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI21/00848Universitat Rovira i Virgili (Rovira i Virgili University) PMF2021-IN000681

6 · The paper itself

Abstract

Cognitive deficits and overweight are prominent challenges in the treatment of psychosis, which have a direct impact on patients' quality of life. We aim to determine whether there is an association of overweight with cognitive performance and whether there are sex differences in this association. We included 170 individuals with first-episode psychosis (FEP) (mean age 23.08 years, 32.9% females) attending an early intervention service who underwent clinical, biometric, and cognitive assessments by the MATRICS Consensus Cognitive Battery. A set of two-way analyses of covariance (ANCOVAs) were conducted for each cognitive test. Sex, overweight, and their interaction were included as factors. Nearly 34% of the participants were overweight without differences between males and females. The excess of weight did not exert any main effect on cognition; however, overweight females performed significantly worse than non-overweight females in processing speed, verbal learning and memory, reasoning and problem-solving, and global cognitive function, whereas in males, there were no differences. Our findings highlight that sex matters in the study of metabolic and cognitive factors in FEP to develop targeted interventions based on sex perspectives.

Identifiers

PMID39438485

DOI10.1038/s41537-024-00521-w

PMCPMC11496804

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.