Evidence map›Paper›PMID 39438628›Full record

Observational studyScientific reports2024

Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study.

Qin Zhang, Xiaoxiong Huang, Yazhong Zhang, Zhujun Chao, Ruoran Zhou, Roslida Abd Hamid, Yunfang Zhen, Yusheng Li, Cheng Huang, Wu Xu and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qin Zhang *Department of Orthopaedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P.R. China.
Xiaoxiong Huang *Department of Orthopaedics, Ningbo No. 2 Hospital, Ningbo, 315000, Zhejiang, P.R. China.
Yazhong Zhang *Department of Orthopaedics, The Second Affiliated Hospital of XuZhou Medical University, Xuzhou, 221000, Jiangsu, P.R. China.
Zhujun ChaoMedical college, Soochow University, Suzhou, 215006, Jiangsu, P.R. China.
Ruoran ZhouMedical college, Soochow University, Suzhou, 215006, Jiangsu, P.R. China.
Roslida Abd HamidDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, 43400, Selangor, Malaysia.
Yunfang ZhenDepartment of Orthopaedics, Children's hospital of Soochow University, Suzhou, 215000, Jiangsu, P.R. China.
Yusheng LiDeparment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.
Cheng HuangDeparment of Orthopaedics, China-Japan Friendship Hospital, Beijing, P.R. China. hcheng90@outlook.com.
Wu XuDepartment of Orthopaedics, First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215000, Jiangsu, P.R. China. xuwu@suda.edu.cn.
Jun LinDepartment of Orthopaedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P.R. China. linjun@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Walking pace is a simple and functional form of exercise and a strong predictor of health, but little is known about its causal association with rheumatoid arthritis. This study aimed to investigate the causal effect of WP on the developing RA using Mendelian randomization analysis. The genetic variation associated with WP was selected as an instrumental variable from the latest genome-wide association studies. Summary-level data for the outcomes were obtained from the corresponding GWAS. The inverse-variance weighted method was used as the primary MR analysis. The results were further tested using a multivariable MR approach based on Bayesian model averaging. Confounders (BMI, SMK, HBP, TD) with close associations with RA were included in the analysis. An observational study with individual data from UK Biobank was performed to reinforce our findings. The MR results indicated the significant inverse associations of WP with the risk of RA (odds ratio (OR), 0.31; 95% confidence interval (CI), 0.15, 0.62; p = 1.05 × 10 -3). After adjusting for the risk factors, the associations for WP and RA did not change substantially. Observational study results demonstrated the same effect of WP on reducing the risk of RA. The Mendelian randomization analysis and observational study provide evidence suggesting that walking pace is a protective factor for rheumatoid arthritis. Given its simple measurement, walking pace may be a pragmatic target for interventions.

Indexed as

Arthritis, RheumatoidGenome-Wide Association StudyMendelian Randomization AnalysisBayes TheoremFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideProtective FactorsRisk FactorsWalking SpeedCausal associationMendelian randomizationMR-BMARheumatoid arthritisWalking pace

Identifiers

PMID39438628
PMCPMC11496810

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.