Evidence map›Paper›PMID 39438798›Full record

ArticleBMC geriatrics2024

What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study.

Chunyang Pang, Yufei Chen, Yinuo Chen, Er Lin, Xinnan Pan, Yiting Xu, Huan Yu, Wanli Zhang, Binbin Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunyang PangDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China.
Yufei ChenDepartment of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, P R China.
Yinuo ChenThe first clinical medical college of Wenzhou Medical University, Wenzhou, P R China.
Er LinThe first clinical medical college of Wenzhou Medical University, Wenzhou, P R China.
Xinnan PanThe first clinical medical college of Wenzhou Medical University, Wenzhou, P R China.
Yiting XuDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China.
Huan YuDepartment of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, P R China.
Wanli ZhangDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China.
Binbin DengDepartment of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China. dbinbin@aliyun.com.

Funding

the Natural Science Foundation of Zhejiang Province ZCLY24H0903
6 · The paper itself

Abstract

backgroundPost-stroke stress can trigger instant survival but its influence on long-term ischemic stroke outcomes remains controversial. Thus, we sought to explore the associations of acute post-stroke stress evidenced by endocrine and metabolic changes, with long-term ischemic stroke outcomes.

methodsAdmissions for acute ischemic stroke within seven days of onset were prospectively recruited to determine acute endocrine and metabolic variations measured by thyroid parameters and the stress hyperglycemia ratio (SHR). Long-term ischemic stroke prognoses were followed up for one year, with the primary outcome being a modified Rankin Scale score of 3 to 6.

resultsA total of 887 patients were enrolled, of which 535 reached the final one-year followed up at a poor prognosis rate of 29.3%. Patients with poor outcomes were observed to have lower levels of free triiodothyronine (fT3) and higher levels of SHR on admission. Medium values (fT3, 4.4 mmol/L; SHR, 8 nmol/L) were used to divide patients into four gradient stress degrees. Larger acute endocrine and metabolic variations (fT3 < 4.4 mmol/L and SHR ≥ 8 nmol/L) were independently associated with a poor one-year prognosis (adjusted OR = 4.231, P = 0.001).

conclusionsHigh degrees of acute post-stroke stress may aggravate long-term ischemic stroke prognosis and timely stress-reduced interventions may help promote post-stroke living quality is equally important as survival.

Indexed as

Ischemic StrokeAgedAged, 80 and overFemaleHumansHyperglycemiaMaleMiddle AgedPrognosisProspective StudiesTriiodothyronineTriiodothyronineAcute ischemic strokeStressStress hyperglycemiaStroke prognosisThyroid hormones

Identifiers

PMID39438798
PMCPMC11515757

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.