ArticleInfluenza and other respiratory viruses2024
Seasonality and Co-Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness-Valencia Region, Spain, 2010-2021.
Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Eco-Evolutionary Dynamics of Pathogen Epidemic Timing in a Seasonal Environment.Ecology letters · 2026Article
- Symptom Trajectories and Long-Term Sequelae of COVID-19: A Matched Case-Control Study with Population-Based Controls.Journal of clinical medicine · 2026Article
- Impact of immune status on respiratory virus prevalence and co-detection patterns: a retrospective analysis (2019-2024).BMC pulmonary medicine · 2026Article
- Epidemiology of HMPV and Other Respiratory Viral Infections Among Outpatients, 2016-2022.Open forum infectious diseases · 2026Article
- Epidemiology of human RSV in Taiwan, 2018-2024.PloS one · 2026Article
- Integrating Surveillance and Stakeholder Insights to Predict Influenza Epidemics: A Bayesian Network Study in Queensland, Australia.International journal of environmental research and public health · 2026Article
- Development of a single-tube, dual-target CRISPR Cas12a/Cas13a system for rapid screening of coinfection with respiratory syncytial virus and rhinovirus.Virology journal · 2025Article
- Respiratory viral infections in hospitalized adults: a comparative clinico-laboratory study of RSV, HMPV, and influenza.Virology journal · 2025Article
- Long-term impact of the SARS-CoV-2 pandemic on respiratory viruses in Germany.BMC public health · 2025Article
- Seasonal Incidence of Human Metapneumovirus in High-Risk Adults With Medically Attended Acute Respiratory Illness in a Rural US Community.Influenza and other respiratory viruses · 2025Article
- Pathogen Profile of Children Hospitalised with Viral Respiratory Infections in Galati County, Romania.Viruses · 2025Article
- Co-detection of various viruses in SARS-CoV-2 in children with respiratory infections.Scientific reports · 2025Article
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Abstract
backgroundRespiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co-circulation and interaction between viruses is critical to prevention and management. We use > 10-year active surveillance in the Valencia Region to assess seasonality and co-circulation.
methodsOver 2010-2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real-time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS-CoV-2 and non-SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co-detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation.
resultsMost viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December-February, as did HCoV and SARS-CoV-2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co-infection. Multiple viruses were found in 4% of patients, with more common co-detection in children under 5 (9%) than older ages. Influenza co-detection was generally observed infrequently relative to expectation, while RSV co-detections were more common, particularly among young children.
conclusionsWe identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co-detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co-detection, meriting further study.
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