Evidence map›Paper›PMID 39439956›Full record

ArticleFrontiers in oncology2024

The mutated in colorectal cancer (

Huonggiang Nguyen, Qingzhi Huang, Uijin Juang, Suhwan Gwon, Woohyeong Jung, Soohyeon Lee, Beomwoo Lee, So Hee Kwon, In Soo Kim, Jongsun Park and 1 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huonggiang Nguyen *Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Qingzhi Huang *Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Uijin JuangDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Suhwan GwonDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Woohyeong JungDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Soohyeon LeeDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Beomwoo LeeDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
So Hee KwonCollege of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea.
In Soo KimDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Jongsun ParkDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.
Seon-Hwan KimDepartment of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The mutated in colorectal cancer (MCC) gene was initially identified as a candidate tumor suppressor gene in colorectal cancer, acting as a negative regulator of cell cycle progression. However, its functional roles in brain tumors, particularly glioblastoma, remain largely unexplored. This study reveals a significant association between MCC status and glioblastoma. Methods: We explored MCC expression in the glioblastoma database, patient samples, and cell lines. We investigated the proliferation and migration of the cell lines in MCC gene knockdown using small interfering RNA. Results: Discussion: These findings indicate that MCC expression is significantly upregulated in glioblastoma and may play a role in its pathophysiology, warranting further investigation.

Indexed as

biomarkerbraincancerglioblastomaMCC

Identifiers

PMID39439956
PMCPMC11493605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.