Evidence map›Paper›PMID 39440975›Full record

ArticlemBio2024

T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by

Claire M Doherty, Paige R Patterson, Julie A Emeanuwa, Jessica Belmares Ortega, Barbara A Fox, David J Bzik, Eric Y Denkers

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claire M DohertyCenter for Evolutionary and Theoretical Immunology and Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0002-2583-3258
Paige R PattersonCenter for Evolutionary and Theoretical Immunology and Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.
Julie A EmeanuwaCenter for Evolutionary and Theoretical Immunology and Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.
Jessica Belmares OrtegaCenter for Evolutionary and Theoretical Immunology and Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.
Barbara A FoxDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
David J BzikDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID 0000-0002-8592-4733
Eric Y DenkersCenter for Evolutionary and Theoretical Immunology and Department of Biology, University of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0001-9020-3327

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Unravelling MyD88-dependent and independent mucosal immunity to ToxoplasmaR01AI139628 · NIAID · UNIVERSITY OF NEW MEXICO · PI ERIC Y DENKERS · 2018 to 2026
$3.6M
Metabolic basis for the persistence of dormant Toxoplasma gondii infectionR01AI172811 · NIAID · DARTMOUTH COLLEGE · PI DAVID J BZIK · 2023 to 2026
$1.6M
New insights into early T cell protection during acute toxoplasmosisR21AI170657 · NIAID · UNIVERSITY OF NEW MEXICO · PI DENKERS, ERIC Y · 2022 to 2023
$411k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI139628HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI170657HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI172811NCI NIH HHS P30 CA118100NIAID NIH HHS R01 AI139628NIAID NIH HHS R01 AI172811NIAID NIH HHS R21 AI170657
6 · The paper itself

Abstract

As a model organism in the study of immunity to infection,

Indexed as

Interleukin-10Mice, KnockoutProtozoan ProteinsToxoplasmaAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDown-RegulationMiceMice, Inbred C57BLMyeloid Differentiation Factor 88T-LymphocytesToxoplasmosisCytokinesIL10 protein, mouseInterleukin-10Myeloid Differentiation Factor 88Protozoan ProteinscytokinesT-cell immunityToxoplasma gondii

Identifiers

PMID39440975
PMCPMC11559025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.