Evidence map›Paper›PMID 39441338›Full record

ArticleProbiotics and antimicrobial proteins2025

Effect of Probiotics on Sperm Quality in the Adult Mouse.

Ana Sanchez-Rodriguez, Ingrid I D Idrovo, Rocío Villafranca, Nerea Latorre, Juan Antonio Rielo, Ane Laburu, Sandra Nieto-Román, Daniel Heredia, Rubén González, Virginia García-Cañas and 4 more

Abstract read
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The effects of polysaccharides fromFrontiers in veterinary science · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana Sanchez-RodriguezDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-3724-9470
Ingrid I D IdrovoDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.
Rocío VillafrancaDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.
Nerea LatorreDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.
Juan Antonio RieloDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.
Ane LaburuDepartment of Biogeography and Global Change, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain.
Sandra Nieto-RománBioCoRe S. Coop. Calle Primitiva Gañan 11, 28026, Madrid, Spain.
Daniel HerediaBioCoRe S. Coop. Calle Primitiva Gañan 11, 28026, Madrid, Spain.
Rubén GonzálezBioCoRe S. Coop. Calle Primitiva Gañan 11, 28026, Madrid, Spain.
Virginia García-CañasMolecular Nutrition and Metabolism, Institute of Food Science Research (CSIC), Calle Nicolás Cabrera 9, 29049, Madrid, Spain.ORCID http://orcid.org/0000-0001-6728-4325
Diego LaxaldeMolecular Nutrition and Metabolism, Institute of Food Science Research (CSIC), Calle Nicolás Cabrera 9, 29049, Madrid, Spain.
Carolina SimóMolecular Nutrition and Metabolism, Institute of Food Science Research (CSIC), Calle Nicolás Cabrera 9, 29049, Madrid, Spain.ORCID http://orcid.org/0000-0002-7140-0795
David R VieitesDepartment of Ecology and Marine Resources, Institute of Marine Research (CSIC), Rúa Eduardo Cabello 6, 36208, Vigo, Spain.ORCID http://orcid.org/0000-0001-5551-7419
Eduardo R S RoldanDepartment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales (CSIC), Calle José Gutierrez Abascal 2, 28006, Madrid, Spain. roldane@mncn.csic.es.ORCID http://orcid.org/0000-0002-7545-4248

Funding

Agrupación de Interés Económico Probiosperm 20196967Madrid Regional Government PEJ-2019-TL/AMB-15136Spanish Ministry of Science, Innovation and Universities CGL 2016-80577-PSpanish Ministry of Science, Innovation and Universities and European Social Fund FJC2019-041736-IWellcome Trust 228205
6 · The paper itself

Abstract

The administration of probiotics for the treatment of different diseases has gained interest in recent years. However, few studies have evaluated their effects on reproductive traits. The objective of this study was to examine the effect of two mixtures of probiotics, a commercial probiotic (Vivomixx®) and a mix of Lacticaseibacillus rhamnosus GG and Faecalibacterium duncaniae A2-165, on sperm quality in a mouse model. Adult male mice (8 months old) were used for two experimental and one control groups (n = 5 each). The probiotics or physiological serum (control) was administered orally, twice a week, during 5 weeks. Sperm were collected from the cauda epididymis, and their total number, motility, kinematics, morphology, and acrosome integrity were assessed in recently collected samples and after a 60-min in vitro incubation. Results showed a higher percentage of normal sperm in both experimental groups, with fewer head abnormalities than in the control. Differences were found among groups in the morphometry of sperm heads, being more elongated in mice treated with probiotics. Sperm from probiotic-treated mice showed similar total motility when compared to the controls, although the proportion of progressively moving sperm and their vigor of motility were lower. Sperm swimming descriptors were measured with a CASA system. Velocity parameters were similar among groups whereas linearity was higher in mice treated with the commercial probiotic. These results suggest that the administration of probiotics may increase the proportion of sperm with normal morphology and lead to modifications in sperm head shape that may enhance sperm swimming. Studies using a longer administration period would be useful in further characterizing the effect of these probiotic mixtures on sperm quality and fertilization capacity.

Indexed as

ProbioticsSpermatozoaAnimalsLacticaseibacillus rhamnosusMaleMiceSemen AnalysisSperm MotilityFaecalibacterium duncaniae A2-165Lacticaseibacillus rhamnosus GGProbioticsSperm evaluationVivomixx®

Identifiers

PMID39441338
PMCPMC12634785

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.