Evidence map›Paper›PMID 39441702›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

An Ultrahigh Affinity DNA Aptamer for Quinine and Its Intrinsic Fluorescence Based Label-Free Detection.

Meheta Datta, Yunus A Kaiyum, Philip E Johnson, Juewen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meheta DattaDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Yunus A KaiyumDepartment of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3J 1P3, Canada.ORCID https://orcid.org/0009-0001-3086-9124
Philip E JohnsonDepartment of Chemistry, York University, 4700 Keele St., Toronto, Ontario, M3J 1P3, Canada.ORCID https://orcid.org/0000-0002-5573-4891
Juewen LiuDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.ORCID https://orcid.org/0000-0001-5918-9336

Funding

Natural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

Measuring quinine is critical for the detection of its overdose, understanding its pharmacological and toxicological effects, and monitoring its pollution. While a previously reported aptamer named MN4 can bind quinine, it was not selected for it, leading to compromised binding affinity and specificity. In this work, a new quinine aptamer was isolated using the library immobilization capture-SELEX technique. The Q1 aptamer has a K

Indexed as

Aptamers, NucleotideQuinineSELEX Aptamer TechniqueSpectrometry, FluorescenceBiosensing TechniquesCocaineFluorescenceLimit of DetectionAptamers, NucleotideCocaineQuinineAptamersBiosensorsFluorescenceQuinineSELEX

Identifiers

PMID39441702
PMCPMC11711290

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.