Evidence map›Paper›PMID 39441930›Full record

ArticleScience advances2024

Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution.

Sangami Pugazenthi, Bhuvic Patel, Collin W English, William A Leidig, Kyle P McGeehan, Colin R McCornack, Shinghei Mok, Markus Anzaldua-Campos, Shervin Hosseingholi Nouri, Kaleigh Roberts and 8 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sangami PugazenthiDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5179-5232
Bhuvic PatelDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8062-7310
Collin W EnglishDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3730-2793
William A LeidigDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Kyle P McGeehanDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5614-217X
Colin R McCornackDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7781-1456
Shinghei MokDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0000-2105-8883
Markus Anzaldua-CamposDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Shervin Hosseingholi NouriDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0002-9454-6700
Kaleigh RobertsDepartment of Neuropathology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6483-9153
Ajay ChatrathDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1309-9612
A KhanDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Ron GadotDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Hiroko YanoDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Tiemo J KlischDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8182-384X
Akdes S HarmanciThe Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6374-9041
Akash J PatelThe Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1280-2989
Albert H KimDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1751-8493

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Establishing the Genomic Landscape of Human Atypical MeningiomasK08NS102474 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI PATEL, AKASH J. · 2017 to 2021
$869k
NIGMS NIH HHS T32 GM007200NINDS NIH HHS K08 NS102474
6 · The paper itself

Abstract

An important subset of meningiomas behaves aggressively and is characterized by multiple recurrences. We identify clinical, genetic, and epigenetic predictors of multiply recurrent meningiomas (MRMs) and evaluate the evolution of these meningiomas in patient-matched samples. On multivariable binomial logistic regression, MRMs were significantly associated with male sex (

Indexed as

DNA MethylationMeningeal NeoplasmsMeningiomaNeoplasm Recurrence, LocalAdultAgedDNA Copy Number VariationsEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedRisk Factors

Identifiers

PMID39441930
PMCPMC11498213

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.