Evidence map›Paper›PMID 39442038›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2024

Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.

Eleonora A Grasso, Luke Bloy, Phillip Kaplan, Amit Bar-Or, E Ann Yeh, Douglas L Arnold, Sridar Narayanan, Ruth Ann Marrie, Giulia Fadda, Brenda L Banwell and 1 more

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In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Correlates of long-term clinical outcomes in pediatric multiple sclerosis: A 12-year study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleonora A GrassoFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.
Luke BloyFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0001-5061-851X
Phillip KaplanFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.
Amit Bar-OrFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0001-7179-0335
E Ann YehFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-5393-7417
Douglas L ArnoldFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0003-4266-0106
Sridar NarayananFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.
Ruth Ann MarrieFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-1855-5595
Giulia FaddaFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0001-9658-815X
Brenda L BanwellFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0001-6354-6770
Canadian Demyelinating Disease NetworkFrom the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesRecent studies suggest that the choroid plexus (CP) may function as a site of access of inflammatory cells into the CNS in multiple sclerosis (MS). Pediatric-onset MS (POMS) is characterized by a high inflammatory burden, as evidenced by a high relapse rate and volume of T2 lesions, making patients with POMS an informative population to evaluate choroid plexus volume (CPV). The objectives of the study were (1) to evaluate CPV at symptom onset in participants with POMS compared with healthy controls (HCs); (2) to evaluate changes in CPV in the first year of disease in participants with POMS; and (3) to evaluate associations between CPV, brain volumes, relapse activity, and disability in participants with POMS.

methodsBaseline 1.5T MRI scans were acquired from 23 participants with POMS and 23 age-matched and sex-matched HCs; 18 participants with POMS also had 12-month follow-up MRI scans. The CP of the lateral ventricles was segmented manually. CP and brain structure volumes were normalized for total intracranial volume. The number of relapses, T2 and gadolinium-enhancing T1 lesion counts, and Expanded Disability Status Scale (EDSS) scores at 12 months were also analyzed. Baseline CPVs were compared between groups using the Wilcoxon exact test, and CPV change from baseline to 12 months in participants with POMS was compared using the Wilcoxon signed-rank test. The relationship between CPV and brain volumetric measures, T2 lesion volumes, lesion count, number of relapses, and EDSS scores was assessed through Spearman correlation.

resultsThe median normalized CPV was 1.51 × 10 DISCUSSION: CPV measured at baseline is greater in participants with POMS than in HCs. Baseline CPV did not predict higher disease activity or worse neurologic outcomes over 1 year. While higher CPV may be an early feature of inflammation in MS, its strong correlation with ventricular volumes could also reflect enlargement secondary to the mechanical attachment of CP to the ventricular wall.

Indexed as

Choroid PlexusMagnetic Resonance ImagingMultiple SclerosisAdolescentAdultAge of OnsetChildFemaleFollow-Up StudiesHumansMaleOrgan SizeYoung Adult

Identifiers

PMID39442038
PMCPMC11502105

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.