ArticleNeurology2024
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults.
Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Harnessing Brain Age-Specific Effects on the Associations Between Sleep Quality, Glymphatic Function, and Cognition in Normal Ageing Adults: Insights for Gerotherapeutics.Neurology and therapy · 2026Article
- Association between life's essential 8 and epilepsy: A cross-sectional study (NHANES 2013-2018).Medicine · 2026Article
- Life's essential 8 health profiles and risk of incident neuropsychiatric diseases: a nationwide prospective cohort study.BMC psychiatry · 2026Article
- LifeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Association of the cumulative modified life's Essential 8 score with cognitive change: Results from two longitudinal cohorts.The journal of prevention of Alzheimer's disease · 2026Article
- Social determinants disadvantage score and liver health in the All of Us Research Program.European journal of epidemiology · 2026Article
- Radar Multiple Bin Selection for Breathing and Heart Rate Monitoring in Acute Stroke Patients in a Clinical Setting.Sensors (Basel, Switzerland) · 2025Article
- DNA methylation signatures of Life's Essential 8 and their implications for dementia.Alzheimer's research & therapy · 2025Article
- Deep learning-based brain age predicts stroke recurrence in acute ischemic cerebrovascular disease.NPJ digital medicine · 2025Article
- An mHealth App (NeoMayor) to Promote Healthy Lifestyles and Brain Health in Older Adults: Design and Validation Study.JMIR aging · 2025Article
- Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Adherence to Life's Essential 8 enhances gut microbiota diversity and cognitive performance.Frontiers in microbiomes · 2025Article
- Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
objectivesMounting evidence points to a strong connection between cardiovascular risk during middle age and brain health later in life. The American Heart Association's Life's Essential 8 (LE8) constitutes a research and public health construct capturing key determinants of cardiovascular health. However, the overall effect of the LE8 on global, clinically relevant metrics of brain health is still unknown. We tested the hypothesis that worse LE8 profiles are associated with higher composite risk of the most important clinical endpoints related to poor brain health.
methodsWe conducted a two-stage (discovery and replication) prospective study using data from the UK Biobank (UKB) and All of Us (AoU), 2 large population studies in the United Kingdom and the United States, respectively. The primary exposure was the LE8 score, a validated tool that captures 8 modifiable cardiovascular risk factors (blood pressure, glucose, cholesterol, body mass index, smoking, physical activity, diet, and sleep duration), organized in 3 categories (optimal, intermediate, and poor). The primary outcome was a composite of stroke, dementia, or late-life depression. We evaluated associations using multivariable Cox proportional hazard models.
resultsThe discovery stage included 316,127 UKB participants (mean age 56, 52% female). Over a mean (SD) follow-up time of 4.9 (0.4) years, the unadjusted risk of the composite outcome was 0.7% (95% CI 0.61-0.74), 1.2% (95% CI 1.11-1.22), and 1.8% (95% CI 1.70-1.91) in participants with optimal, intermediate, and poor cardiovascular health, respectively ( DISCUSSION: Among middle-aged adults enrolled in 2 large population studies, poor cardiovascular health profiles were associated with two-fold higher risk of developing a composite outcome that captures the most important diseases related to poor brain health. Because the evaluated risk factors are all modifiable, our findings highlight the potential brain health benefits of using the Life's Essential 8 to guide cardiovascular health optimization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.