Evidence map›Paper›PMID 39442673›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2024

Histological validation of three-dimensional variable flip angle turbo spin echo multi-contrast magnetic resonance vessel wall imaging in characterizing carotid vulnerable atherosclerotic plaques.

Jiachen Liu, Zihan Ning, Chenlin Du, Shuo Chen, Tao Wang, Jingli Cao, Ran Huo, Dongye Li, Dandan Yang, Rui Shen and 5 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiachen LiuCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Zihan NingCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China; Department of Perinatal Imaging and Health, King's College London, London, United Kingdom.
Chenlin DuCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Shuo ChenCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Tao WangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, China.
Jingli CaoChina National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ran HuoDepartment of Radiology, Peking University Third Hospital, Beijing, China.
Dongye LiDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Dandan YangDepartment of Radiology, Beijing Geriatric Hospital, Beijing, China.
Rui ShenCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Shuwan YuCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Chunjiang HuCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China.
Shuhao WangThorough Images, Beijing, China.
Huiyu QiaoSchool of Biomedical Engineering, Capital Medical University, Beijing, China. Electronic address: qiaohuiyu98@ccmu.edu.cn.
Xihai ZhaoCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China. Electronic address: xihaizhao@tsinghua.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate assessment of the vulnerability of carotid atherosclerotic plaques is crucial for stroke prevention. The three-dimensional (3D) magnetic resonance (MR) vessel wall imaging (VWI) has been increasingly employed to evaluate carotid plaques due to its extensive coverage and isotropic high spatial resolution. However, the accuracy of such techniques lacks validation by histology. Therefore, this study aims to validate the accuracy of 3D multi-contrast MR VWI with variable-flip-angle (VFA) and turbo spin echo (TSE) readout in identifying vulnerable carotid plaques, using histological analysis as a reference.

methodsTwenty-one male patients (mean age: 64.4 ± 7.2 years old) scheduled for carotid endarterectomy (CEA) were recruited in this study. All patients underwent carotid multi-contrast MR VWI, including 3D T1- and T2-weighted VFA-TSE sequences, as well as 3D time of flight (TOF) MR angiography (MRA), using a 3.0T MR system before surgery. Histological processing was performed for carotid plaque specimens. The presence or absence, along with the area measurements, of lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH), and calcifications (CA) were independently evaluated on both MR images and histological sections. Cohen's kappa (κ) analysis was utilized to determine the agreement between 3D multi-contrast MR VWI and histology in identifying carotid plaque compositions before and after excluding compositions bellow certain size threshold. Spearman's correlation analysis was also conducted to assess the agreement in quantifying plaque compositions.

resultsA total of 81 slices of MR images were successfully matched with histological sections. Moderate to almost perfect agreements were observed between 3D MR VWI and histology in the identification of LRNC (κ: 0.85 and 0.89), IPH (κ: 0.65 and 0.69), and CA (κ: 0.46 and 0.62) before and after excluding compositions smaller than 0.79 mm

conclusionThe 3D VFA-TSE multi-contrast MR VWI is capable of accurately characterizing vulnerable carotid atherosclerotic plaques.

Indexed as

Carotid ArteriesEndarterectomy, CarotidImaging, Three-DimensionalMagnetic Resonance AngiographyPlaque, AtheroscleroticPredictive Value of TestsAgedBiopsyCarotid Artery DiseasesCarotid StenosisContrast MediaHumansImage Interpretation, Computer-AssistedMaleMiddle AgedNecrosisContrast MediaAtherosclerosisCarotid arteryHistologyMagnetic resonance imagingVulnerable plaque

Identifiers

PMID39442673
PMCPMC11655683

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.