ArticleNature2024
Transgelin 2 guards T cell lipid metabolism and antitumour function.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
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Who cites it
54 citing papers in PubMed.
- Subtype-specific mechanisms of lipid metabolism in gynecological malignancies and novel targeted intervention strategies (Review).Oncology letters · 2026Review
- Metabolic rewiring of the dendritic cell-T cell axis: tumour-derived barriers and therapeutic opportunities.Experimental & molecular medicine · 2026Review
- LOX-1 mediated lipid peroxidation leads to dysfunction of tumor infiltrating CD8Redox biology · 2026Article
- Cell-type-specific polygenic risk scores reveal adipocyte-related interactions with lipids in coronary artery disease.medRxiv : the preprint server for health sciences · 2026Article
- TGF-β2 drives lipid droplet accumulation in chondrocytes through the TβRI/p-smad3/fabp5 axis.The Journal of biological chemistry · 2026Article
- A guide to CAR T cell therapies: development, current status and future prospects.Nature reviews. Immunology · 2026Review
- Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application.MedComm · 2026Review
- Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer.Nature immunology · 2026Article
- Rethinking ovarian cancer III: the past decade and future directions.Nature reviews. Cancer · 2026Review
- Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy.Oncogenesis · 2026Review
- Tumor-Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lipid metabolism reprogramming shapes the immune landscape in the tumor microenvironment.Cellular & molecular immunology · 2026Review
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- Development of a metabolic subtype classifier for low-grade glioma to guide precision therapy.Discover oncology · 2026Article
- Effect of Vitrification on Lipidomics in Porcine Cumulus-Oocyte Complexes After In Vitro Maturation.Cells · 2026Article
- Natural Compounds as Epimodulators in Epithelial Ovarian Cancer.Epigenomes · 2026Review
- Metabolic reprogramming of CAR-T cells: a multi-pronged strategy to conquer the immunosuppressive tumor microenvironment.Cell communication and signaling : CCS · 2026Review
- Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer.Signal transduction and targeted therapy · 2026Article
- Microenvironmental regulation of solid tumour resistance to CAR T cell therapy.Nature reviews. Immunology · 2026Review
- Targeting organelle function in T cells for cancer immunotherapy.Nature reviews. Immunology · 2026Review
Corrections and comments
- Update of
Authors and funding
25 authors.
Sung-Min HwangDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4868-147X
Deepika AwasthiDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Jieun JeongCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tito A SandovalDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-2705-5282
Chang-Suk ChaeDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Yusibeska RamosDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Chen TanDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Matías Marin FalcoResearch Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Camilla SalvagnoDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Alexander EmmanuelliDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Ian T McBainWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Bikash MishraWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0002-7351-2096
Lionel B IvashkivWeill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0002-9951-0646
Dmitriy ZamarinTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Evelyn CantilloDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Eloise Chapman-DavisDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Kevin HolcombDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Diana K MoralesDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Xiaoqing YuDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jose R Conejo-GarciaDepartment of Integrated Immunobiology, Duke School of Medicine, Durham, NC, USA.ORCID 0000-0001-6431-4074
Martin KaczochaDepartment of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0002-2527-1398
Anna VähärautioResearch Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-4721-3954
Minkyung SongDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-2668-7528
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA. jur2016@med.cornell.edu.ORCID 0000-0002-4267-4893
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MFc Receptors &Cytokine Balance in Rheumatoid ArthritisR01AR050401 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI Lionel B Ivashkiv · 2004 to 2026
$7.4MDevelopment of the Next Generation of FABP5 Inhibitors to Treat Prostate CancerR01CA237154 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN, OJIMA, IWAO · 2020 to 2024
$3.3MER stress-driven IRE1a-XBP1 signaling in lung cancerR01CA271619 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz, Vivek Mittal · 2023 to 2026
$2.6MPOTENTIATION OF ANTI-TUMOR IMMUNITY BY ONCOLYTIC VIRUS IN SITU VACCINATIONR01CA269382 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Dmitriy Zamarin · 2023 to 2026
$2.5MImmunometabolic Programs Controlled by ER Stress in CancerR01CA282072 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz · 2023 to 2026
$2.3MPlant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1MEndoplasmic Reticulum Stress Responses in PainR01NS114653 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOADA, MARIO DANILO, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2024
$2.0MMitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumorsR01CA273034 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2022 to 2025
$1.9MLinear Ion Trap - Quadrupole LC-MS SystemS10OD032292 · OD · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2022 to 2022
$592kTriple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425kNCI NIH HHS F31 CA257631NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA237154NCI NIH HHS R01 CA262121NCI NIH HHS R01 CA269382NCI NIH HHS R01 CA271619NCI NIH HHS R01 CA273034NCI NIH HHS R01 CA282072NCRR NIH HHS S10 RR027926NIAMS NIH HHS R01 AR050401NIH HHS S10 OD032292NINDS NIH HHS R01 NS114653
Abstract
Mounting effective immunity against pathogens and tumours relies on the successful metabolic programming of T cells by extracellular fatty acids
Indexed as
CD8-Positive T-LymphocytesLipid MetabolismMicrofilament ProteinsMuscle ProteinsOvarian NeoplasmsAnimalsCell Line, TumorCell RespirationEndoplasmic Reticulum StressFatty Acid-Binding ProteinsFatty AcidsFemaleHumansMiceMice, Inbred C57BLMitochondriaFABP5 protein, humanFatty Acid-Binding ProteinsFatty AcidsMicrofilament ProteinsMuscle ProteinsReceptors, Chimeric AntigenTagln2 protein, human
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.