Evidence map›Paper›PMID 39444403›Full record

ArticleHeliyon2024

Typical NF2 and LTZR1 mutations are retained in an immortalized human schwann cell model of schwannomatosis.

Valentina Melfi, Tasnim Mohamed, Alessandra Colciago, Alessandra Fasciani, Raffaele De Francesco, Daniela Bettio, Cristina Cerqua, Francesca Boaretto, Elisabetta Basso, Stefano Ferraresi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Valentina MelfiDept. of Pharmacological and Biomolecular Science "R. Paoletti" Università degli Studi di Milano, Italy.
Tasnim MohamedDept. of Pharmacological and Biomolecular Science "R. Paoletti" Università degli Studi di Milano, Italy.
Alessandra ColciagoDept. of Pharmacological and Biomolecular Science "R. Paoletti" Università degli Studi di Milano, Italy.
Alessandra FascianiHuman Technopole, Milan, Italy.
Raffaele De FrancescoDept. of Pharmacological and Biomolecular Science "R. Paoletti" Università degli Studi di Milano, Italy.
Daniela BettioClinical Genetics Unit, Dept. of Women's and Children's Health, University of Padova, Italy.
Cristina CerquaClinical Genetics Unit, Dept. of Women's and Children's Health, University of Padova, Italy.
Francesca BoarettoClinical Genetics Unit, Dept. of Women's and Children's Health, University of Padova, Italy.
Elisabetta BassoDept. of Neurosurgery, Ospedale Santa Maria della Misericordia, Rovigo, Italy.
Stefano FerraresiDept. of Neurosurgery, Ospedale Santa Maria della Misericordia, Rovigo, Italy.
Marco MontiniDept. of Experimental and Clinical, Medical Genetics Unit, Biomedical Sciences "Mario Serio," University of Florence, Florence, Italy.
Marica EoliNeuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Laura PapiDept. of Experimental and Clinical, Medical Genetics Unit, Biomedical Sciences "Mario Serio," University of Florence, Florence, Italy.
Eva TrevissonClinical Genetics Unit, Dept. of Women's and Children's Health, University of Padova, Italy.
Valerio MagnaghiDept. of Pharmacological and Biomolecular Science "R. Paoletti" Università degli Studi di Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human SCs play a primary role in SWN, a rare genetic disorder in which patients develop multiple schwannomas. So that, their isolation and immortalization could represent an irreplaceable tool to investigate the disease etiopathology. Although few clones of tumoural SCs have been obtained, unfortunately they present genetic, morphological and biological characteristics that do not fully represent the original cells. Herein we isolated, characterized and immortalized primary SCs from human schwannomas. Our immortalized human SCs present typical

Identifiers

PMID39444403
PMCPMC11497399

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.