Transcriptome analyses reveal common immune system dysregulation in PAH patients and
Grégoire Ruffenach, Hélène Le Ribeuz, Mary Dutheil, Kristell El Jekmek, Florent Dumont, Anaïs Saint-Martin Willer, Marc Humbert, Véronique Capuano, Lejla Medzikovic, Mansoureh Eghbali and 2 more
Article in Pulmonary circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Grégoire RuffenachDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine University of California Los Angeles USA.ORCID 0000-0001-6419-4332
Hélène Le RibeuzFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Mary DutheilFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Kristell El JekmekFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Florent DumontFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Anaïs Saint-Martin WillerFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.ORCID 0000-0002-2078-3271
Marc HumbertFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Véronique CapuanoFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Lejla MedzikovicDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine University of California Los Angeles USA.
Mansoureh EghbaliDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine University of California Los Angeles USA.
David MontaniFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.
Fabrice AntignyFaculté de Médecine, Le Kremlin-Bicêtre Université Paris-Saclay Le Kremlin-Bicêtre France.ORCID 0000-0002-9515-6571
Funding
Role of intestinal inflammation in oxidized lipid induced pulmonary hypertensionR01HL162124 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH, REDDY, SRINIVASA T. · 2022 to 2025
$2.4M
Role of miR125 in pulmonary hypertension secondary to interstitial lung diseaseR01HL147586 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2020 to 2023
$1.9M
Role of Chromosome Y gene, Uty, in protecting against Pulmonary HypertensionR01HL159865 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2021 to 2024
Pulmonary arterial hypertension (PAH) is a severe disease caused by progressive distal pulmonary artery obstruction. One cause of PAH are loss-of-function mutations in the potassium channel subfamily K member 3 (KCNK3). KCNK3 encodes a two-pore domain potassium channel, which is crucial for pulmonary circulation homeostasis. However, our understanding of the pathophysiological mechanisms underlying KCNK3 dysfunction in PAH is still incomplete. Taking advantage of unique
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Transcriptome analyses reveal common immune system dysregulation in PAH patients and · full record | Socratic