ArticleJournal of thoracic disease2024
Opportunity for severe and critical COVID-19 pneumonia treatment with corticosteroids: a retrospective cohort study.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development and validation of a pneumonia severity prediction model using AI analysis of abdominal and paravertebral intramuscular fat on chest CT in COVID-19 patients.Journal of thoracic disease · 2025Article
- Convalescent plasma therapy for COVID-19 in patients with nasal catheter oxygen therapy.Journal of thoracic disease · 2025Article
- Aortic valve calcification in echocardiography is a prognostic factor for short-term adverse outcomes in elderly patients with severe COVID-19: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Observational
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Authors and funding
6 authors.
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Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic has been the most significant infectious disease outbreak worldwide in the past 3 years, with the potential to progress to severe pneumonia and trigger systemic inflammatory response, posing a threat to human health and life. This study aims to explore the use of corticosteroids for COVID-19 and provide recommendations on the timing and dosage of the treatment. Methods: We conducted a retrospective cohort study, enrolling 100 with COVID-19 pneumonia between December 2022 and January 2023. The diagnosis of severe and critical COVID-19 pneumonia patients was according to China's Ninth Edition of the Diagnosis and Treatment Plan for COVID-19 Pneumonia. T test and univariate proportional hazard analysis were employed to investigate the opportunity of corticosteroids therapy in relation to patients' prognosis. Results: Compared to COVID-19 pneumonia patients treated with corticosteroids in the early phase, those who received late-phase corticosteroid therapy had a higher proportion of intensive care unit (ICU) admission (P=0.01), longer hospital stay (P=0.006), lower in-hospital survival rate (P=0.03), and slower recovery (P<0.001). A significant difference was also observed in logistic univariate proportional hazard analysis. Conclusions: The early administration of corticosteroid therapy has been shown to significantly improve the prognosis of COVID-19 pneumonia patients, promoting recovery with significant clinical significance. Our recommendation for the administration of corticosteroid therapy is to be applied on the 6th-9th day of persisting unrelieved symptoms of COVID-19 pneumonia.
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