Evidence map›Paper›PMID 39446130›Full record

ArticleAmerican journal of physiology. Renal physiology2024

The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption.

Dipak Maskey, Tang-Dong Liao, D'Anna L Potter, Pablo A Ortiz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Salt and chronic kidney disease.Nature reviews. Nephrology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dipak MaskeyHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, United States.ORCID 0009-0003-4535-1883
Tang-Dong LiaoHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, United States.
D'Anna L PotterHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, United States.
Pablo A OrtizHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, United States.ORCID 0000-0002-7512-7255

Funding

Regulation of NKCC2 and renal NaCl transport by protein-protein interactionsR01DK131114 · NIDDK · WAYNE STATE UNIVERSITY · PI Pablo A. Ortiz · 2023 to 2026
$2.2M
Regulation of NKCC2 and renal NaCl transport by protein-protein interactionsR56DK131114 · NIDDK · WAYNE STATE UNIVERSITY · PI ORTIZ, PABLO A. · 2021 to 2021
$100k
HHS | National Institutes of Health (NIH) R01DK131114A1NIDDK NIH HHS R01 DK131114NIDDK NIH HHS R56 DK131114
6 · The paper itself

Abstract

In the kidney, the thick ascending limb (TAL) of the loop of Henle plays a vital role in NaCl homeostasis and blood pressure regulation. In human and animal models of salt-sensitive hypertension, NaCl reabsorption via the apical Na

Indexed as

ActininLoop of HenleSolute Carrier Family 12, Member 1AnimalsHumansMaleRenal ReabsorptionSodium ChlorideActininACTN4 protein, humanSLC12A1 protein, humanSlc12a1 protein, mouseSlc12a1 protein, ratSodium ChlorideSolute Carrier Family 12, Member 1FSGS protein actinin-4NaCl reabsorptionNKCC2 traffickingprotein-protein interactionthick ascending limb

Identifiers

PMID39446130
PMCPMC11687841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.