Atrial cardiomyopathy resulting from loss of plakophilin-2 expression: Response to adrenergic stimulation and implications for the exercise response.
Kavya Phadke, Sergio D'Anna, Estefania Torres Vega, Junhua Xiao, Xianming Lin, Mingliang Zhang, Joseph Sall, Feng-Xia Liang, David S Park, Marina Cerrone and 3 more
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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5 · Who and what money
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13 authors.
Kavya PhadkeThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Sergio D'AnnaDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0009-1349-5157
Estefania Torres VegaDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Junhua XiaoThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Xianming LinThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Mingliang ZhangThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Joseph SallDART Microscopy Laboratory, New York University Grossmann School of Medicine, New York, NY, USA.
Feng-Xia LiangDART Microscopy Laboratory, New York University Grossmann School of Medicine, New York, NY, USA.ORCID 0000-0003-0037-4590
David S ParkThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Marina CerroneThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.
Alicia LundbyDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1612-6041
Mario DelmarThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.ORCID 0000-0002-2085-5589
Chantal J M van OpbergenThe Leon Charney Division of Cardiology, New York University Grossmann School of Medicine, New York, NY, USA.ORCID 0000-0002-1656-4447
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Molecular Atlas of the Cardiac Intercalated DiscR35HL160840 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mario Delmar · 2022 to 2026
$5.0M
Functional interaction between cardiac Na channels and KATP channelsR01HL148609 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A, DELMAR, MARIO · 2020 to 2023
$2.7M
Scanning Electron Microscope with 3ViewS10OD019974 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, FENGXIA · 2016 to 2016
Atrial arrhythmias occur in 20-40% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and are associated with an increased risk of sustained ventricular arrhythmias and inappropriate implantable cardioverter-defibrillator shocks. The pathophysiology of atrial arrhythmias in ARVC remains unclear. Most cases of gene-positive ARVC are linked to pathogenic variants in the desmosomal gene plakophilin-2 (PKP2). Here, we test the hypothesis that loss of PKP2 expression leads to pro-arrhythmic changes in atrial cardiomyocytes. Atrial cells/tissue were obtained from a cardiac-specific, tamoxifen-activated model of PKP2 deficiency (PKP2cKO). By contrast to PKP2cKO ventricular myocytes, PKP2cKO atrial cardiomyocytes presented no significant differences in intracellular calcium (Ca
Indexed as
Arrhythmogenic Right Ventricular DysplasiaExerciseHeart AtriaPlakophilinsAction PotentialsAnimalsCalciumHumansIsoproterenolMaleMiceMyocytes, CardiacReactive Oxygen SpeciesSarcoplasmic ReticulumCalciumIsoproterenolPlakophilinsReactive Oxygen Speciesadrenergic stimulationarrhythmogenic right ventricular cardiomyopathyatrial fibrillationoxidative stressplakophilin‐2ryanodine receptor
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
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