Evidence map›Paper›PMID 39447473›Full record

ArticleEnvironment international2024

Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes.

Danielle R Stevens, Sophia M Blaauwendraad, Paige A Bommarito, Michiel van den Dries, Leonardo Trasande, Suzanne Spaan, Anjoeka Pronk, Henning Tiemeier, Romy Gaillard, Vincent W V Jaddoe and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. [A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Pesticides and human health.Jornal de pediatria
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Danielle R StevensEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC, United States.
Sophia M BlaauwendraadThe Generation R Study Group, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands.
Paige A BommaritoEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC, United States.
Michiel van den DriesISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Leonardo TrasandeDepartment of Pediatrics, Division of Environmental Pediatrics, NYU Grossman School of Medicine, New York, NY, United States; Department of Population Health, NYU Grossman School of Medicine, New York, NY, United States; NYU Wagner School of Public Service, New York, NY, United States.
Suzanne SpaanDepartment of Risk Analysis for Products in Development, TNO, Utrecht, 3584 CB, the Netherlands.
Anjoeka PronkDepartment of Risk Analysis for Products in Development, TNO, Utrecht, 3584 CB, the Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Erasmus University Medical Centre, Rotterdam, the Netherlands; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Romy GaillardThe Generation R Study Group, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands.
Vincent W V JaddoeThe Generation R Study Group, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands.
Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC, United States. Electronic address: Kelly.ferguson2@nih.gov.

Funding

Preconceptual Bisphenol and Phthalate Effects on Early Embryonic DevelopmentR01ES029779 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2018 to 2023
$2.7M
Phthalates, BPA, Trajectories of In and Ex Utero Growth and Cardiometabolic RisksR01ES022972 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2014 to 2018
$2.7M
The Generation R cohort study as an NIEHS resourceZIAES101575 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2009 to 2025
$1.2M
Phthalates and Phthalate Alternatives and Early Human Cardiometabolic DevelopmentR00ES035107 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Danielle Stevens · 2025 to 2026
$495k
Intramural NIH HHS ZIA ES101575NIEHS NIH HHS HHSN273201500003CNIEHS NIH HHS HHSN273201500003ONIEHS NIH HHS R00 ES035107NIEHS NIH HHS R01 ES022972NIEHS NIH HHS R01 ES029779
6 · The paper itself

Abstract

introductionThe general population is chronically exposed to organophosphate pesticides through various routes including ingestion, hand-to-mouth contact, inhalation, and dermal contact. Exposure to organophosphate pesticides during pregnancy impairs fetal development, but the potential long-term effects of gestational organophosphate pesticide exposure are less well understood.

methodsWe investigated associations between gestational organophosphate pesticide exposure and cardiovascular outcomes in 643 children in the Generation R Study, a prospective pregnancy cohort based in Rotterdam, The Netherlands. Urinary organophosphate pesticide metabolites (dimethyl [∑DMAP], diethyl [∑DEAP], and total dialkyl phosphate [∑DAP] metabolites) were quantified in three urine samples collected from pregnant participants, and their children were followed until age 10 years at which time cardiac magnetic resonance imaging, ultrasonography, blood pressure, and serum biomarkers assessed cardiovascular health. Linear regression models estimated associations (β and 95 % confidence interval [CI]) between a one-interquartile range (IQR) increase in averaged gestational exposure biomarker concentrations and z-scored pediatric cardiovascular outcomes. We investigated effect modification of associations by PON1 genotype.

resultsCarotid intima-media thickness z-score was lower (β: -0.14 [95 % CI: -0.25, -0.02]) and HDL cholesterol z-score was higher (β: 0.14 [95 % CI: 0.02, 0.25]) for increases in ∑DEAP concentrations. Carotid intima-media distensibility z-score was lower (β: -0.08 [95 % CI: -0.19, 0.03]) for increases in ∑DMAP concentrations, and systolic blood pressure z-score was higher (β: 0.10 [95 % CI: -0.01, 0.21]) for increases in ∑DMAP and ∑DAP. Among those with PON1-161CC and PON1-L55MTT genotypes, higher organophosphate pesticide concentrations conferred an excess risk of adverse vascular and glycemic outcomes, respectively.

conclusionsWe observed heterogenous associations between gestational organophosphate pesticide exposure and pediatric cardiovascular health: an anti-atherogenic profile was observed for increases in ∑DEAP concentrations, and impairments in multiple aspects of cardiovascular health was observed for increases in ∑DMAP concentrations. PON1-161 and PON1-L55M single nucleotide polymorphisms modified associations for vascular and glycemic outcomes, respectively.

Indexed as

AryldialkylphosphataseMaternal ExposurePesticidesPrenatal Exposure Delayed EffectsAdultBiomarkersCardiovascular DiseasesCarotid Intima-Media ThicknessChildChild, PreschoolEnvironmental PollutantsFemaleHumansInfantMaleNetherlandsAryldialkylphosphataseBiomarkersEnvironmental PollutantsOrganophosphatesOrganophosphorus CompoundsPesticidesPON1 protein, humanCardiovascular diseasesEndocrine disruptersGene polymorphismOrganophosphatesPesticidesPregnancyProspective Studies

Identifiers

PMID39447473
PMCPMC11585415

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.