Evidence map›Paper›PMID 39449061›Full record

ArticleStem cell research & therapy2024

Adipose-derived mesenchymal stem cells inhibit hepatic stellate cells activation to alleviate liver fibrosis via Hippo pathway.

Haifeng Liu, Haocheng Huang, Yifan Liu, Yuxue Yang, Hongchuan Deng, Xinmiao Wang, Ziyao Zhou, Guangneng Peng, Shouchao Jin, Dechun Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haifeng LiuDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China. hfliu@sicau.edu.cn.ORCID 0000-0002-7495-9332
Haocheng HuangDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Yifan LiuDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Yuxue YangDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Hongchuan DengDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Xinmiao WangDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Ziyao ZhouDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Guangneng PengDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Shouchao JinSichuan Jinbei Banshan Group Co Ltd, Chengdu, 610041, China.
Dechun ChenCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China. chendechun@swun.edu.cn.
Zhijun ZhongDepartment of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China. zhongzhijun488@sicau.edu.cn.

Funding

National Natural Science Foundation of China No. 32002353Natural Science Foundation of Sichuan Province No. 2022NSFSC1680
6 · The paper itself

Abstract

backgroundLiver fibrosis is a common pathological process of chronic liver disease, characterized by excessive deposition of extracellular matrix (ECM). Mesenchymal stem cells (MSCs) have been found to have potential therapy effect on liver fibrosis, but the mechanism involved was still unclear. The objective of this study is to investigate the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADMSCs) on the treatment of liver fibrosis, with particular emphasis on elucidating the underlying mechanism of action through which ADMSCs inhibit the activation of hepatic stellate cells (HSCs).

methodsADMSCs were isolated from adipose tissue and injected intravenously into hepatic fibrosis model of rats. The histopathological changes, liver function, collagen deposition, the expression of fibroin and Hippo pathway were evaluated. In vitro, ADMSCs were co-cultured with HSCs activated by transforming growth factor beta

resultsThe results showed that after the transplantation of ADMSCs, the liver function of rats was improved, the degree of liver fibrosis and collagen deposition were reduced, and the Hippo signaling pathway was activated. In vitro, ADMSCs can effectively inhibit the proliferation and activation of HSCs induced by TGF-β

conclusionsADMSCs inhibit HSCs activation by regulating YAP/TAZ, thereby promoting functional recovery after liver fibrosis. These findings lay a foundation for further investigation into the precise mechanism by which ADMSCs alleviate liver fibrosis.

Indexed as

Hepatic Stellate CellsHippo Signaling PathwayLiver CirrhosisMesenchymal Stem CellsMesenchymal Stem Cell TransplantationProtein Serine-Threonine KinasesRats, Sprague-DawleySignal TransductionYAP-Signaling ProteinsAcyltransferasesAdipose TissueAnimalsMaleRatsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsAcyltransferasesProtein Serine-Threonine KinasesTafazzin protein, ratTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTransforming Growth Factor beta1WWTR1 protein, ratYap1 protein, ratYAP-Signaling ProteinsHepatic stellate cellsHippo PathwayLiver fibrosisMesenchymal stem cellsTherapeutics

Identifiers

PMID39449061
PMCPMC11515333

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.