Evidence map›Paper›PMID 39449221›Full record

ArticleSmall methods2025

Scalable Copper Sulfide Formulations for Super-Resolution Optoacoustic Brain Imaging in the Second Near-Infrared Window.

Lin Tang, Daniil Nozdriukhin, Sandeep Kumar Kalva, Quanyu Zhou, Çağla Özsoy, Shuxin Lyu, Michael Reiss, Anxo Vidal, Ana Torres, Xosé Luís Deán-Ben and 1 more

Abstract read
In one paragraph

Article in Small methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lin TangInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.ORCID 0009-0008-3399-1134
Daniil NozdriukhinInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Sandeep Kumar KalvaInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Quanyu ZhouInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Çağla ÖzsoyInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Shuxin LyuInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Michael ReissInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Anxo VidalCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS) and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Ana TorresExperimental Biomedicine Centre (CEBEGA), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Xosé Luís Deán-BenInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.
Daniel RazanskyInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, 8057, Switzerland.ORCID 0000-0001-8676-0964

Funding

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin SupplementRF1NS126102 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CAMPBELL, ROBERT E., RAZANSKY, DANIEL · 2022 to 2024
$3.1M
NINDS NIH HHS RF1 NS126102Swiss Innovation Agency 51767.1IP-LSSwiss National Science Foundation 310030_192757US National Institutes of Health RF1-NS126102
6 · The paper itself

Abstract

Optoacoustic imaging offers label-free multi-parametric characterization of cerebrovascular morphology and hemodynamics at depths and spatiotemporal resolution unattainable with optical microscopy. Effective imaging depth can greatly be enhanced by employing photons in the second near-infrared (NIR-II) window. However, diminished absorption by hemoglobin along with a lack of suitable contrast agents hinder an efficient application of the technique in this spectral range. Herein, copper sulfide (CuS) micro- and nano-formulations for multi-scale optoacoustic imaging in the NIR-II window are introduced. Dynamic contrast enhancement induced by intravenously administered CuS nanoparticles facilitated visualization of blood perfusion in murine cerebrovascular networks. The individual calcium carbonate microparticles carrying CuS are further shown to generate sufficient responses to enable super-resolution microvascular imaging and blood flow velocity mapping with localization optoacoustic tomography.

Indexed as

BrainCopperPhotoacoustic TechniquesSulfidesAnimalsCerebrovascular CirculationContrast MediaMiceNanoparticlesContrast MediaCoppercupric sulfideSulfideschemical imagingmicroparticle localizationneuroimagingoptoacoustic imagingphotoacousticssecond near‐infrared window

Identifiers

PMID39449221
PMCPMC11740951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.