Evidence mapPaperPMID 39449867Full record

ReviewBiophysics reviews2024

Engineered tools to study endocrine dysfunction of pancreas.

Charles G Alver, Juan Dominguez-Bendala, Ashutosh Agarwal

Abstract readReview
In one paragraph

Review in Biophysics reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juan Dominguez-BendalaDiabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.ORCID https://orcid.org/0000-0001-9410-9143

Funding

Using ex vivo, in vivo models and patient mutations to interrogate pancreatic exocrine-endocrine cross talkU01DK135095 · JOSLIN DIABETES CENTER · 2025 to 2025
$882k
BMP signaling and regenerative plasticity: Correlating dynamic scRNAseq and real-time anatomical remodeling in T1D pancreatic slicesR01DK138210 · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2025 to 2025
$513k
NIDDK NIH HHS F31 DK132916NIDDK NIH HHS R01 DK130846NIDDK NIH HHS R01 DK138210NIDDK NIH HHS U01 DK135095NIDDK NIH HHS UH3 DK122638
6 · The paper itself

Abstract

Pancreas, a vital organ with intricate endocrine and exocrine functions, is central to the regulation of the body's glucose levels and digestive processes. Disruptions in its endocrine functions, primarily regulated by islets of Langerhans, can lead to debilitating diseases such as diabetes mellitus. Murine models of pancreatic dysfunction have contributed significantly to the understanding of insulitis, islet-relevant immunological responses, and the optimization of cell therapies. However, genetic differences between mice and humans have severely limited their clinical translational relevance. Recent advancements in tissue engineering and microfabrication have ushered in a new era of

Identifiers

PMID39449867
PMCPMC11498943

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.