ArticleCureus2024
Floral Fusion: Unravelling the Potent Blend of Ixora coccinea and Rhododendron arboreum for Health and Safety Benefits.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective
methodsIn vitro antioxidant activity against reactive oxygen species (ROS) was measured using the ferric-reducing ability of plasma (FRAP), nitric oxide (NO), and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assays, while anti-inflammatory effects were assessed via the membrane stabilization method. Docking studies were performed to evaluate the interaction of phytochemicals - anthocyanins, quercetin, and ursolic acid, which are present in these plants - with nuclear factor kappa B (NF-κB), cyclooxygenase-1 (COX-1), and cyclooxygenase-2 (COX-2). Standard protocols were used to evaluate embryotoxicity using the brine shrimp model and cytotoxicity using the zebrafish model, which is crucial for determining safe clinical dosages.
resultsThe analysis revealed diverse bioactive compounds, including anthocyanins, quercetin, and ursolic acid. The formulation effectively inhibited ROS production at lower concentrations (inhibitory concentration 50%, or IC50 value ~2.8 µg/mL), indicating their potential for managing oxidative stress. Quercetin demonstrated the strongest interaction with all tested proteins, particularly NF-kB. Cytotoxicity and embryotoxicity assays revealed a dose-dependent effect (lethal concentration 50%, or LC50 value 82.4 µg/mL), with no adverse effects on developing embryos at the tested doses (5-80 µg/mL), suggesting the extracts are safe for clinical use, even during pregnancy.
conclusionThe combined extracts of
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.