Evidence mapPaperPMID 39450137Full record

ArticleJCEM case reports2024

Liraglutide for the Treatment of Severe Hypoglycemia Following Total Pancreatectomy and Islet Autotransplantation.

Christopher Chan, Wayne Hawthorne, Henry Pleass, Deborah Jane Holmes-Walker

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher ChanDepartment of Diabetes & Endocrinology, Westmead Hospital, Westmead, NSW 2145, Australia.ORCID https://orcid.org/0009-0002-6397-8025
Wayne HawthorneWestmead Clinical School, University of Sydney, Westmead, NSW 2145, Australia.ORCID https://orcid.org/0000-0001-8638-3468
Henry PleassWestmead Clinical School, University of Sydney, Westmead, NSW 2145, Australia.ORCID https://orcid.org/0000-0002-9814-0452
Deborah Jane Holmes-WalkerDepartment of Diabetes & Endocrinology, Westmead Hospital, Westmead, NSW 2145, Australia.ORCID https://orcid.org/0000-0002-3640-1370

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Total pancreatectomy and islet autotransplantation (TPIAT) is an effective treatment for chronic and recurrent acute pancreatitis, and it provides a significant potential additional benefit of insulin independence. Spontaneous hypoglycemia in the absence of insulin therapy following TPIAT is a recognized complication, which has been attributed to lack of protective glucagon responses to hypoglycemia, following intrahepatic islet autotransplantation. We describe the use of liraglutide to treat spontaneous hypoglycemia following TPIAT. Continuous glucose monitoring was used to identify timing of hypoglycemia in relation to meals and monitor treatment effect. Liraglutide has been used for management of hypoglycemia following bariatric surgery, but, to our knowledge, this is the first application of its effective use to treat spontaneous severe hypoglycemia following TPIAT.

Indexed as

chronic pancreatitishypoglycemiaislet cell autotransplantationtotal pancreatectomy

Identifiers

PMID39450137
PMCPMC11500716

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.