Evidence map›Paper›PMID 39451191›Full record

ArticleCells2024

EF24, a Curcumin Analog, Reverses Interleukin-18-Induced miR-30a or miR-342-Dependent TRAF3IP2 Expression, RECK Suppression, and the Proinflammatory Phenotype of Human Aortic Smooth Muscle Cells.

Yusuke Higashi, Ryan Dashek, Patrice Delafontaine, Randy Scott Rector, Bysani Chandrasekar

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yusuke HigashiMedicine/Cardiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0003-1956-0182
Ryan DashekNextGen Precision Health, University of Missouri, Columbia, MO 65211, USA.
Patrice DelafontaineMedicine/Cardiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0003-3744-3617
Randy Scott RectorNextGen Precision Health, University of Missouri, Columbia, MO 65211, USA.
Bysani ChandrasekarResearch Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.

Funding

CTSA UM1 at the University of Alabama at BirminghamUM1TR004771 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATRICE DELAFONTAINE, Orlando M Gutierrez · 2024 to 2026
$29.2M
Insulin-Like Growth Factor-1and AtherosclerosisR01HL070241 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PATRICE DELAFONTAINE · 2003 to 2026
$10.1M
RECK regulation of NASH and fibrosisR01DK130243 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI BYSANI, CHANDRASEKAR, RECTOR, RANDY SCOTT · 2022 to 2025
$2.2M
Role of novel RNA binding protein LARP6 in alcoholic cardiomyopathyR21AA029747 · NIAAA · LSU HEALTH SCIENCES CENTER · PI BYSANI, CHANDRASEKAR, GARDNER, JASON DAVIN · 2023 to 2024
$413k
Hepatic eNOS in the regulation of NASHI01BX003271 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI RANDY SCOTT RECTOR · 2017 to 2026
–
BLRD Research Career Scientist Award ApplicationIK6BX004016 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI Chandrasekar Bysani · 2018 to 2026
–
RECK in Adverse Cardiac Remodeling and Heart FailureI01BX005845 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI BYSANI, CHANDRASEKAR · 2022 to 2025
–
BLRD VA I01 BX003271BLRD VA I01 BX005845BLRD VA IK6 BX004016NCATS NIH HHS UM1 TR004771NHLBI NIH HHS HL070241NHLBI NIH HHS R01 HL070241NIAAA NIH HHS R21 AA029747NIAAA NIH HHS R21AA029747NIDDK NIH HHS DK130243NIDDK NIH HHS R01 DK130243US Department of Veterans Affairs I01 BX005845,US Department of Veterans Affairs IK6BX004016
6 · The paper itself

Abstract

Curcumin, a polyphenolic compound derived from the widely used spice

Indexed as

AortaCurcuminGPI-Linked ProteinsInterleukin-18MicroRNAsMyocytes, Smooth MusclePhenotypeAdaptor Proteins, Signal TransducingCells, CulturedHumansInflammationAdaptor Proteins, Signal TransducingCurcuminGPI-Linked ProteinsInterleukin-18MicroRNAsRECK protein, humanTRAF3IP2 protein, humanatherosclerosiscell proliferationcurcumininflammationmigrationvascular proliferative diseases

Identifiers

PMID39451191
PMCPMC11505909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.