Evidence mapPaperPMID 39452071Full record

ReviewBiology2024

Contemporary Update on Clinical and Experimental Prostate Cancer Biomarkers: A Multi-Omics-Focused Approach to Detection and Risk Stratification.

Sana Hachem, Amani Yehya, Jad El Masri, Nicole Mavingire, Jabril R Johnson, Abdulrahman M Dwead, Naim Kattour, Yazan Bouchi, Firas Kobeissy, Soroush Rais-Bahrami and 3 more

Abstract readReview
In one paragraph

Review in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Integrating multi-omics data for next-generation cancer research and precision medicine.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Biomarkers in Localized Prostate Cancer: From Diagnosis to Treatment.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sana HachemDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.
Amani YehyaDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.ORCID 0009-0000-5544-7318
Jad El MasriDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.
Nicole MavingireDepartment of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA.ORCID 0000-0003-1485-0519
Jabril R JohnsonDepartment of Microbiology, Biochemistry, & Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.ORCID 0000-0001-5998-7733
Abdulrahman M DweadDepartment of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Naim KattourDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.ORCID 0009-0003-1239-7359
Yazan BouchiDepartment of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Firas KobeissyDepartment of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.ORCID 0000-0002-5008-6944
Soroush Rais-BahramiDepartment of Urology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-9466-9925
Yehia MechrefDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6661-6073
Wassim Abou-KheirDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, Lebanon.ORCID 0000-0001-9719-9324
Leanne Woods-BurnhamDepartment of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA.

Funding

Georgia Clinical & Translational Science Alliance (Georgia CTSA)UL1TR002378 · EMORY UNIVERSITY · 2025 to 2025
$9.3M
Research Capacity CoreU54MD007602 · MOREHOUSE SCHOOL OF MEDICINE · 2025 to 2025
$4.8M
RESEARCH TRAINING AND CAREER DEVELOPMENTU54CA118638 · MOREHOUSE SCHOOL OF MEDICINE · 2005 to 2025
$2.1M
Institutional Career Development CoreKL2TR002381 · EMORY UNIVERSITY · 2025 to 2025
$1.5M
Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · 2022 to 2025
$972k
J. NRSA Training CoreTL1TR002382 · EMORY UNIVERSITY · 2025 to 2025
$932k
Department of Defense Prostate Cancer Research Program W81XWH2110038NCATS NIH HHS KL2 TR002381NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NCI NIH HHS U01 CA225753NCI NIH HHS U54 CA118638NIGMS NIH HHS R01 GM112490NIGMS NIH HHS R01 GM130091NIH HHS 1R01GM112490NIH HHS 1R01GM130091NIH HHS 1U01CA225753NIH HHS KL2TR002381NIH HHS TL1TR002382NIH HHS UL1TR002378NIH/NCI U54CA118638NIH/NIMHD 2U54MD007602NIMHD NIH HHS U54 MD007602Prostate Cancer Foundation 20YOUN04Robert A. Welch Foundation D-0005The CH Foundation N/A
6 · The paper itself

Abstract

Prostate cancer remains a significant health challenge, being the most prevalent non-cutaneous cancer in men worldwide. This review discusses the critical advancements in biomarker discovery using single-omics and multi-omics approaches. Multi-omics, integrating genomic, transcriptomic, proteomic, metabolomic, and epigenomic data, offers a comprehensive understanding of the molecular heterogeneity of prostate cancer, leading to the identification of novel biomarkers and therapeutic targets. This holistic approach not only enhances the specificity and sensitivity of prostate cancer detection but also supports the development of personalized treatment strategies. Key studies highlighted include the identification of novel genes, genetic mutations, peptides, metabolites, and potential biomarkers through multi-omics analyses, which have shown promise in improving prostate cancer management. The integration of multi-omics in clinical practice can potentially revolutionize prostate cancer prognosis and treatment, paving the way for precision medicine. This review underscores the importance of continued research and the application of multi-omics to overcome current challenges in prostate cancer diagnosis and therapy.

Indexed as

biomarkersmulti-omicsomicsprostate cancer

Identifiers

PMID39452071
PMCPMC11504278

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.