ArticleJournal of cardiovascular development and disease2024
FGFR4 Is Required for Concentric Growth of Cardiac Myocytes during Physiologic Cardiac Hypertrophy.
Isaac Campos, Beatrice Richter, Sarah Madison Thomas, Brian Czaya, Christopher Yanucil, Dominik Kentrup, Abul Fajol, Qing Li, Stephen M Secor, Christian Faul
Abstract read
In one paragraphArticle in Journal of cardiovascular development and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Isaac CamposSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-9430-597X Beatrice RichterSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Sarah Madison ThomasSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Brian CzayaSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-7888-2432 Christopher YanucilSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Dominik KentrupSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Abul FajolSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qing LiSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-4540-7915 Stephen M SecorDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA.
Christian FaulSection of Mineral Metabolism, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-7512-0977 Funding
Changes in phosphate metabolism cause pathologic cardiac remodeling in chronic kidney disease (CKD)R01HL145528 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FAUL, CHRISTIAN, WHITE, KENNETH E · 2019 to 2022
$2.4MHyperphosphatemia Contributes to Systemic Inflammation and Anemia in Chronic Kidney DiseaseR01DK125459 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAUL, CHRISTIAN · 2020 to 2023
$1.5MHyperphosphatemia Contributes to Cardiac Injury in Chronic Kidney DiseaseF31DK127640 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CAMPOS, ISAAC D · 2022 to 2024
$143kVitamin D and soluble Klotho inhibit FGF23-mediated cardiac hypertrophy in Chronic Kidney DiseaseF31DK115074 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YANUCIL, CHRISTOPHER · 2017 to 2019
$106kFGF23 contributes to anemia in Chronic Kidney Disease by elevating hepcidin productionF31DK117550 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CZAYA, BRIAN · 2018 to 2020
$102kNHLBI NIH HHS R01 HL145528NIDDK NIH HHS F31 DK115074NIDDK NIH HHS F31 DK117550NIDDK NIH HHS F31 DK127640NIDDK NIH HHS R01 DK125459NIH HHS 1F31DK127640-24A3NIH HHS 1R01DK125459-24A4NIH HHS 1R01HL145528-24A4
6 · The paper itselfAbstract
Fibroblast growth factor (FGF) 23 is a bone-derived hormone that promotes renal phosphate excretion. Serum FGF23 is increased in chronic kidney disease (CKD) and contributes to pathologic cardiac hypertrophy by activating FGF receptor (FGFR) 4 on cardiac myocytes, which might lead to the high cardiovascular mortality in CKD patients. Increases in serum FGF23 levels have also been observed following endurance exercise and in pregnancy, which are scenarios of physiologic cardiac hypertrophy as an adaptive response of the heart to increased demand. To determine whether FGF23/FGFR4 contributes to physiologic cardiac hypertrophy, we studied FGFR4 knockout mice (FGFR4
Indexed as
FGF23FGFR4physiologic cardiac hypertrophypregnancypython
Identifiers
PMID39452290
PMCPMC11508992
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390