Evidence map›Paper›PMID 39452339›Full record

ArticleInsects2024

Bugs on Drugs: Paracetamol Exposure Reveals Genotype-Specific Generational Effects on Life History Traits in

Birk Nete Randlev Gleerup Hundebøl, Palle Duun Rohde, Torsten Nygaard Kristensen, Rune Wittendorff Mønster Jensen, Thomas Vosegaard, Jesper Givskov Sørensen

Abstract read
In one paragraph

Article in Insects, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Birk Nete Randlev Gleerup HundebølDepartment of Biology, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0003-2916-217X
Palle Duun RohdeDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg Ø, Denmark.ORCID 0000-0003-4347-8656
Torsten Nygaard KristensenDepartment of Chemistry and Bioscience, Aalborg University, 9220 Aalborg Ø, Denmark.ORCID 0000-0001-6204-8753
Rune Wittendorff Mønster JensenInterdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark.ORCID 0009-0006-0727-1323
Thomas VosegaardInterdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0001-5414-4550
Jesper Givskov SørensenDepartment of Biology, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-9149-3626

Funding

Danish Ministry of Higher Education and Science AU-1198 2010-612-181EU H2020 project PANACEA 101008500Novo Nordisk Foundation NNF220C0075797
6 · The paper itself

Abstract

Few investigations have been made to determine whether pharmaceutical drugs cause any generational effects. These effects can be divided into intergenerational and transgenerational effects. In insects, the F1 offspring of exposed individuals are considered to show intergenerational effects (as they have been exposed as germ cells or early embryos), while the F2 generation is fully non-exposed and considered to show transgenerational effects. Here, the common over-the-counter (OTC) drug, paracetamol, is investigated for genotype-specific responses and effects across generations on three life-history traits: fecundity, longevity, and spontaneous locomotor activity levels in the model species

Indexed as

epigenetic inheritancefecunditygenotype by environmentinsect modellongevitypersonalized medicinepharmaceuticalprecision medicinespontaneous activity

Identifiers

PMID39452339
PMCPMC11509061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.