Evidence map›Paper›PMID 39452471›Full record

ReviewDiseases (Basel, Switzerland)2024

The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review.

Ahmed Abu-Zaid, Saleh A K Saleh, Heba M Adly, Saeed Baradwan, Abdullah M Alharran, Mshal Alhatm, Mooza M Alzayed, Muteb N Alotaibi, Abdulbadih Rabih Saad, Hessa Mohammed Alfayadh and 2 more

Abstract readReview
In one paragraph

Review in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Evaluation ofJournal of human reproductive sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmed Abu-ZaidDepartment of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Saleh A K SalehDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0001-9522-9198
Heba M AdlyDepartment of Community Medicine and Pilgrims Healthcare, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0002-9222-9149
Saeed BaradwanDepartment of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Jeddah 23433, Saudi Arabia.ORCID 0000-0003-0427-8758
Abdullah M AlharranCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain.ORCID 0009-0003-2337-6588
Mshal AlhatmCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Mooza M AlzayedCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain.
Muteb N AlotaibiCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Abdulbadih Rabih SaadCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain.
Hessa Mohammed AlfayadhCollege of Medicine, Almaarefa University, Riyadh 13713, Saudi Arabia.
Mohammed AbuzaidDepartment of Obstetrics and Gynecology, Al Birk General Hospital, Al Birk 63525, Saudi Arabia.
Osama AlomarDepartment of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol.

methodsWe systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose-response analyses were performed.

resultsSeventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06-0.70, n = 15, I

conclusionThis meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D's effects on other reproductive hormone parameters.

Indexed as

estradiolfree androgen indexreproductive hormonestestosteronevitamin D

Identifiers

PMID39452471
PMCPMC11506788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.