Evidence mapPaperPMID 39452479Full record

ArticleDiseases (Basel, Switzerland)2024

Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women.

Noemi Venditti, Giulio Petronio Petronio, Antonio Guarnieri, Laura Pietrangelo, Angela Spicciato, Alessio Colalillo, Giovanna Paola Sabusco, Dionisio Franco Barattini, Aldo Di Franco, Stefano Papini and 2 more

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noemi VendittiDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0003-4952-1889
Giulio Petronio PetronioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0002-5098-7785
Antonio GuarnieriDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0003-3949-4143
Laura PietrangeloDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0001-7636-5581
Angela SpicciatoDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.
Alessio ColalilloUO Oncology, Responsible Research Hospital, 86100 Campobasso, Italy.
Giovanna Paola SabuscoDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.
Dionisio Franco BarattiniOpera CRO, a Tigermed Company Strada Cozia N. 10, 300209 Timisoara, Romania.ORCID 0000-0001-9931-6432
Aldo Di FrancoUOC Laboratorio Analisi, Ospedale "A. Cardarelli", 86100 Campobasso, Italy.
Stefano PapiniUO Laboratorio Analisi, Responsible Research Hospital, 86100 Campobasso, Italy.ORCID 0000-0001-5158-5385
Francesco CosentinoDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0002-5698-7946
Roberto Di MarcoDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0001-5075-4597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMenopause, a natural phase in a woman's life, often adversely affects physical, mental, sexual, and emotional well-being due to low estrogen levels. This study examines the impact of vaginal ovules with tocopherol acetate (Filme Gyno-V

methodsFifty women aged 50-70 were divided into menopausal (28) and premenopausal (22) cohorts and treated with the ovules for two weeks, with assessments before and after treatment.

resultsThe findings showed that distressing symptoms of vaginal atrophy, such as dryness, itching, and pain during intercourse, were resolved post-treatment. A molecular analysis revealed a reduction in

conclusionsThis study concludes that Filme Gyno-V ovules may benefit vaginal health by alleviating atrophy symptoms and promoting healthy vaginal microbiota.

Indexed as

eubiosisgenitourinary syndrome (GSM)Lactobacillusmenopausemicrobial diversity indicestocopherol acetatevaginal atrophyvaginal healthvaginal microbiotavitamin E administration

Identifiers

PMID39452479
PMCPMC11506818

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.