Evidence map›Paper›PMID 39452786›Full record

ArticlePathogens (Basel, Switzerland)2024

Interleukin-1 Beta rs16944 and rs1143634 and Interleukin-6 Receptor rs12083537 Single Nucleotide Polymorphisms as Potential Predictors of COVID-19 Severity.

Inas A Ahmed, Taghrid G Kharboush, Hiba S Al-Amodi, Hala F M Kamel, Ehab Darwish, Asmaa Mosbeh, Hossam A Galbt, Amal M Abdel-Kareim, Shimaa Abdelsattar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Inas A AhmedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.ORCID 0000-0001-8518-3827
Taghrid G KharboushDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Hiba S Al-AmodiDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia.ORCID 0000-0003-1865-0004
Hala F M KamelDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia.
Ehab DarwishDepartment of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt.ORCID 0000-0001-5063-2792
Asmaa MosbehDepartment of Pathology, National Liver Institute, Menoufia University, Menoufia 32511, Egypt.
Hossam A GalbtDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Menoufia 32511, Egypt.
Amal M Abdel-KareimDepartment of Zoology, Faculty of Science, Benha University, Benha 13518, Egypt.
Shimaa AbdelsattarDepartment of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Menoufia 32511, Egypt.ORCID 0000-0002-3993-5378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host genetic variation has been recognized as a key predictor of diverse clinical sequelae among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients. Insights into the link between the Interleukin-6 receptor (IL-6R) and Interleukin-1 beta (IL-1β) genetic variation and severe coronavirus disease 2019 (COVID-19) are crucial for developing new predictors and therapeutic targets. We aimed to investigate the association of IL-6R rs12083537, IL-1β rs16944, and IL-1β rs1143634 SNPs with the severity of COVID-19. Our study was conducted on 300 COVID-19-negative individuals (control group) and 299 COVID-19-positive cases, classified into mild, moderate, and severe subgroups. Analyses of IL-1β (rs16944, rs1143634) and IL-6R (rs12083537) SNPs' genotypes were performed using qPCR genotyping assays. The IL-1β (rs16944) CC genotype and IL-6R (rs12083537) GG genotype were substantially related to COVID-19 severity, which was also associated with comorbidities and some laboratory parameters (

Indexed as

COVID-19Interleukin-1betaPolymorphism, Single NucleotideReceptors, Interleukin-6SARS-CoV-2Severity of Illness IndexAdultAgedFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedIL1B protein, humanIL6R protein, humanInterleukin-1betaReceptors, Interleukin-6COVID-19genotypeinterleukin-1 betainterleukin-6 receptorSNPs

Identifiers

PMID39452786
PMCPMC11510688

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.