Evidence map›Paper›PMID 39452882›Full record

ArticleMarine drugs2024

Mechanisms of Action of Sea Cucumber Triterpene Glycosides Cucumarioside A

Ekaterina S Menchinskaya, Ekaterina A Chingizova, Evgeny A Pislyagin, Ekaterina A Yurchenko, Anna A Klimovich, Elena A Zelepuga, Dmitry L Aminin, Sergey A Avilov, Alexandra S Silchenko

Abstract read
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In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. AMarine drugs · 2025
    Article
  4. Anticancer Activity of Triterpene Glycosides Cucumarioside AInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ekaterina S MenchinskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.
Ekaterina A ChingizovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0003-0093-5757
Evgeny A PislyaginG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-3558-0821
Ekaterina A YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0001-7737-0980
Anna A KlimovichG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.
Elena A ZelepugaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-0208-2121
Dmitry L AmininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-1073-4994
Sergey A AvilovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.
Alexandra S SilchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-9367-1158

Funding

Russian Science Foundation 23-13-00078
6 · The paper itself

Abstract

Breast cancer is the most prevalent form of cancer in women worldwide. Triple-negative breast cancer is the most unfavorable for patients, but it is also the most sensitive to chemotherapy. Triterpene glycosides from sea cucumbers possess a high therapeutic potential as anticancer agents. This study aimed to identify the pathways triggered and regulated in MDA-MB-231 cells (triple-negative breast cancer cell line) by the glycosides cucumarioside A

Indexed as

ApoptosisGlycosidesMembrane Potential, MitochondrialReactive Oxygen SpeciesSea CucumbersTriple Negative Breast NeoplasmsTriterpenesAnimalsAntineoplastic AgentsCell Cycle CheckpointsCell Line, TumorCucumariaFemaleHumansMiceMice, Inbred BALB CAntineoplastic AgentscucumariosideGlycosidesReactive Oxygen SpeciesSaponinsTriterpenesanticancer activitybreast cancermitochondrial apoptotic pathwaymolecular mechanismstriterpene glycosides

Identifiers

PMID39452882
PMCPMC11509090

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.