ArticleRadiology. Imaging cancer2024
Deformable Mapping of Rectal Cancer Whole-Mount Histology with Restaging MRI at Voxel Scale: A Feasibility Study.
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Article in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
João Miranda *From the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0003-1273-3108
Jon S Heiselman *From the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0002-4414-8846
Canan FiratFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0002-4731-1303
Jayasree ChakrabortyFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0003-4434-8861
Rami S VanguriFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Antonildes N AssuncaoFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Josip NincevicFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Tae-Hyung KimFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Lee RodriguezFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Nil UrganciFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Mithat GonenFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).
Julio Garcia-AguilarFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0003-2451-0948
Marc J GollubFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0002-6008-0730
Jinru ShiaFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0002-4351-2511
Natally HorvatFrom the Departments of Radiology (J.M., J.N., T.H.K., L.R., M.J.G., N.H.), Surgery (J.S.H., J.C., M.G., J.G.A.), and Pathology (C.F., N.U., J.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of São Paulo, São Paulo, Brazil (J.M., A.N.A., N.H.); Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY (R.S.V.); Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn (J.S.H.); Research and Education Institute, Hospital Sirio-Libanes, São Paulo, Brazil (A.N.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.M., N.H.).ORCID 0000-0001-8849-5789
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
Purpose To develop a radiology-pathology coregistration method for 1:1 automated spatial mapping between preoperative rectal MRI and ex vivo rectal whole-mount histology (WMH). Materials and Methods This retrospective study included consecutive patients with rectal adenocarcinoma who underwent total neoadjuvant therapy followed by total mesorectal excision with preoperative rectal MRI and WMH from January 2019 to January 2022. A gastrointestinal pathologist and a radiologist established three corresponding levels for each patient at rectal MRI and WMH, subsequently delineating external and internal rectal wall contours and the tumor bed at each level and defining eight point-based landmarks. An advanced deformable image coregistration model based on the linearized iterative boundary reconstruction (LIBR) approach was compared with rigid point-based registration (PBR) and state-of-the-art deformable intensity-based multiscale spectral embedding registration (MSERg). Dice similarity coefficient (DSC), modified Hausdorff distance (MHD), and target registration error (TRE) across patients were calculated to assess the coregistration accuracy of each method. Results Eighteen patients (mean age, 54 years ± 13 [SD]; nine female) were included. LIBR demonstrated higher DSC versus PBR for external and internal rectal wall contours and tumor bed (external: 0.95 ± 0.03 vs 0.86 ± 0.04, respectively,
Indexed as
AdenocarcinomaFeasibility StudiesMagnetic Resonance ImagingRectal NeoplasmsAgedFemaleHumansMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingRectumRetrospective StudiesAbdomen/GIMR ImagingOncologyRectum
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