Evidence map›Paper›PMID 39452914›Full record

ArticleMetabolites2024

Comparative Impact of Organic Grass-Fed and Conventional Cattle-Feeding Systems on Beef and Human Postprandial Metabolomics-A Randomized Clinical Trial.

Meghan Spears, Gwendolyn Cooper, Brett Sather, Marguerite Bailey, Jane A Boles, Brian Bothner, Mary P Miles

Abstract read
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meghan SpearsDepartment of Food Systems, Nutrition, and Kinesiology, Montana State University, Bozeman, MT 59717, USA.
Gwendolyn CooperDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-3548-3551
Brett SatherDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Marguerite BaileyDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0009-0002-9982-8117
Jane A BolesDepartment of Animal and Range Sciences, Montana State University, Bozeman, MT 59717, USA.
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-1295-9609
Mary P MilesDepartment of Food Systems, Nutrition, and Kinesiology, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0002-2147-3777

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
NIGMS NIH HHS P20 GM103474
6 · The paper itself

Abstract

BACKGROUND/

objectivesCattle-feeding systems may have health implications for consumers of beef products. Organic grass-fed (GRA) and conventional (CON) cattle-feeding systems may result in beef products with differing metabolite profiles and therefore could impact the postprandial metabolomic response of consumers. This study aims to measure whole beef metabolomics and postprandial metabolomic response of consumers between GRA and CON beef to elucidate potential health implications.

methodsThis study followed a randomized double-blind crossover design with healthy male and female subjects (

resultsCattle-feeding systems impacted both postprandial and whole beef steak metabolomic profiles. Metabolites that contributed to this variation included carnitine species (Proionylcarnitine), fatty acids, amino acids (L-valine), and Calamendiol. These metabolites have been associated with oxidative stress, inflammation, and cardiovascular health. Functional pathway enrichment analysis revealed numerous amino acid degradation pathways, especially branched-chain amino acids, and fatty acid degradation that changed throughout the postprandial time course.

conclusionsThese findings suggest that CON and GRA cattle-feeding systems differentially impact whole beef metabolomics, as well as consumer postprandial metabolic responses and the associated health implications.

Indexed as

beefcattle-feeding systemshealth implicationsmetabolomicspathway enrichmentpostprandialuntargeted

Identifiers

PMID39452914
PMCPMC11509860

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.