Evidence map›Paper›PMID 39453192›Full record

Trial reportToxins2024

Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis.

Larissa Fonseca, Marcia Ribeiro, Júnia Schultz, Natália A Borges, Ludmila Cardozo, Viviane O Leal, Marcelo Ribeiro-Alves, Bruna R Paiva, Paulo E C Leite, Carmen L Sanz and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Relationship between gastroesophageal reflux and chronic kidney disease: A meta-analysis of 4 million patients.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Effects ofLife (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Larissa FonsecaGraduate Program in Medical Sciences, Fluminense Federal University (UFF), Niteroi 24033-900, Brazil.
Marcia RibeiroGraduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 20550-170, Brazil.
Júnia SchultzBioscience Program, Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Makkah 23955, Saudi Arabia.ORCID 0000-0002-8147-4659
Natália A BorgesInstitute of Nutrition, Rio de Janeiro State University (UERJ), Rio de Janeiro 20550-170, Brazil.ORCID 0000-0003-0898-5118
Ludmila CardozoGraduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niteroi 24033-900, Brazil.ORCID 0000-0001-8507-2369
Viviane O LealNutrition Division, Pedro Ernesto University Hospital (UERJ), Rio de Janeiro 20550-170, Brazil.
Marcelo Ribeiro-AlvesHIV/AIDS Clinical Research Center, National Institute of Infectology (INI/Fiocruz), Rio de Janeiro 20550-170, Brazil.
Bruna R PaivaGraduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niteroi 24033-900, Brazil.
Paulo E C LeiteGraduate Program in Science and Biotechnology, Fluminense Federal University (UFF), Niteroi 24033-900, Brazil.ORCID 0000-0002-1783-1228
Carmen L SanzDepartment of Basic Pathology, Federal University of Paraná, Curitiba 81530-000, Brazil.ORCID 0009-0000-8219-3421
Fernanda KussiDepartment of Basic Pathology, Federal University of Paraná, Curitiba 81530-000, Brazil.ORCID 0000-0001-7889-2748
Lia S NakaoDepartment of Basic Pathology, Federal University of Paraná, Curitiba 81530-000, Brazil.ORCID 0000-0001-9647-6350
Alexandre RosadoBioscience Program, Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Makkah 23955, Saudi Arabia.ORCID 0000-0001-5135-1394
Peter StenvinkelDivision of Renal Medicine, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, 17165 Stockholm, Sweden.ORCID 0000-0002-8785-4820
Denise MafraGraduate Program in Medical Sciences, Fluminense Federal University (UFF), Niteroi 24033-900, Brazil.ORCID 0000-0001-6752-6056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPropolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed to evaluate the effects of propolis on the gut microbiota profile and uremic toxin plasma levels in HD patients. These are secondary analyses from a previous double-blind, randomized clinical study, with 42 patients divided into two groups: the placebo and propolis group received 400 mg of green propolis extract/day for eight weeks. Indole-3 acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (p-CS) plasma levels were evaluated by reversed-phase liquid chromatography, and cytokines were investigated using the multiplex assay (Bio-Plex Magpix

Indexed as

Dietary SupplementsFecesGastrointestinal MicrobiomePropolisRenal DialysisUremic ToxinsAgedBacteriaCresolsCytokinesDouble-Blind MethodFemaleHumansIndicanIndoleacetic AcidsMale4-cresol sulfateCresolsCytokinesIndicanindoleacetic acidIndoleacetic AcidsPropolisSulfuric Acid EstersUremic Toxinschronic kidney diseaseCKDhemodialysismicrobiomepropolisuremic toxins

Identifiers

PMID39453192
PMCPMC11511383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.