Evidence map›Paper›PMID 39455280›Full record

ArticleeNeuro2024

Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.

Xiu-Peng Nie, Xiao-Shan Xu, Zhao Feng, Wei Wang, Chen Ma, Yue-Xiong Yang, Jin-Nan Li, Qi-Xin Zhou, Fu-Qiang Xu, Min-Hua Luo and 3 more

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiu-Peng NieUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID https://orcid.org/0009-0008-8807-9521
Xiao-Shan XuUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Zhao FengBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan 430074, China.
Wei WangUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Chen MaUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Yue-Xiong YangUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Jin-Nan LiUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Qi-Xin ZhouUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Fu-Qiang XuShen Zhen Institute of Advanced Technology, Chinese Academy of Sciences, Xi Li Shen Zhen University Town, Shenzhen 518055, China.
Min-Hua LuoState Key Laboratory of Virology and Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Jiang-Ning ZhouChinese Academy of Sciences Centre for Excellence in Brain Science and Intelligent Technology, Shanghai 200031, China.
Hui GongBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan 430074, China huigong@mail.hust.edu.cn lxu@vip.163.com.
Lin XuUniversity of Chinese Academy of Sciences, Beijing 100049, China huigong@mail.hust.edu.cn lxu@vip.163.com.ORCID https://orcid.org/0000-0002-2710-3507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It remains unknown whether the Chinese tree shrew, regarded as the closest sister of primate, has evolved a dorsolateral prefrontal cortex (dlPFC) comparable with primates that is characterized by a fourth layer (L4) enriched with granular cells and reciprocal connections with the mediodorsal nucleus (MD). Here, we reported that following AAV-hSyn-EGFP expression in the MD neurons, the fluorescence micro-optical sectioning tomography revealed their projection trajectories and targeted brain areas, such as the hippocampus, the corpus striatum, and the dlPFC. Cre-dependent transsynaptic viral tracing identified the MD projection terminals that targeted the L4 of the dlPFC, in which the presence of granular cells was confirmed via cytoarchitectural studies by using the Nissl, Golgi, and vGlut2 stainings. Additionally, the L5/6 of the dlPFC projected back to the MD. These results suggest that the tree shrew has evolved a primate-like dlPFC which can serve as an alternative for studying cognition-related functions of the dlPFC.

Indexed as

Dorsolateral Prefrontal CortexTupaiidaeAnimalsFemaleMaleNeural PathwaysNeuronsPrefrontal Cortexdorsolateral prefrontal cortex (dlPFC)fourth layer (L4)granular cellmedial prefrontal cortex (mPFC)mediodorsal nucleus (MD)orbital frontal cortex (OFC)primatetree shrew

Identifiers

PMID39455280
PMCPMC11514722

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.