Evidence map›Paper›PMID 39455282›Full record

ArticleGenes & development2024

Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer.

Hexiao Wang, Claudia Canasto-Chibuque, Jun Hyun Kim, Marcel Hohl, Christina Leslie, Jorge S Reis-Filho, John H J Petrini

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. The RNA Revolution in the Central Molecular Biology Dogma Evolution.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hexiao WangMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Claudia Canasto-ChibuqueMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Jun Hyun KimMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Marcel HohlMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Christina LeslieComputational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Jorge S Reis-FilhoDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
John H J PetriniMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; petrinij@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
DNA Damage & DNA Replication: a Complex RelationshipR35GM136278 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI John HJ Petrini · 2020 to 2026
$5.5M
Regulation of the DNA damage response by the Mre11 complexR37GM059413 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PETRINI, JOHN HJ · 2012 to 2020
$5.2M
The Mre11 complex: linking recombination to checkpointsR01GM059413 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI PETRINI, JOHN HJ · 1999 to 2011
$5.2M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM059413NIGMS NIH HHS R35 GM136278NIGMS NIH HHS R37 GM059413
6 · The paper itself

Abstract

The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic

Indexed as

Breast NeoplasmsInterferonsMRE11 Homologue ProteinOncogenesOrganoidsAnimalsDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticImmunity, InnateMiceTranscription, GeneticDNA-Binding ProteinsInterferonsMre11a protein, mouseMRE11 Homologue Proteinbreast cancerDNA damageinterferon-stimulated geneMRE11 complex

Identifiers

PMID39455282
PMCPMC11610935

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.