Evidence map›Paper›PMID 39456147›Full record

ArticleBiomolecules2024

Cardioprotective Effects of Ursodeoxycholic Acid in Isoprenaline-Induced Myocardial Injury in Rats.

Dalibor Mihajlović, Đorđe Đukanović, Milica Gajić Bojić, Sanja Jovičić, Nebojša Mandić-Kovačević, Snežana Uletilović, Žana M Maksimović, Nebojša Pavlović, Boris Dojčinović, Sergey Bolevich and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dalibor MihajlovićEmergency Department, Primary Healthcare Centre, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Đorđe ĐukanovićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Milica Gajić BojićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.ORCID 0009-0006-8433-7808
Sanja JovičićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Nebojša Mandić-KovačevićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.ORCID 0000-0003-1790-0729
Snežana UletilovićDepartment of Medical Biochemistry and Chemistry, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Žana M MaksimovićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Nebojša PavlovićDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.ORCID 0000-0002-9444-5830
Boris DojčinovićEmergency Department, Primary Healthcare Centre, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Sergey BolevichDepartment of Pathologic Physiology, First Moscow State Medical University I.M. Sechenov, 119435 Moscow, Russia.
Momir MikovDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21101 Novi Sad, Serbia.ORCID 0000-0002-2804-0624
Ranko ŠkrbićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.ORCID 0000-0002-6643-1781
Nada BanjacEmergency Department, Primary Healthcare Centre, 78000 Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.
Velibor VasovićDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21101 Novi Sad, Serbia.ORCID 0000-0003-3974-5547

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients suffering from cholelithiasis have an increased risk of developing cardiovascular complications, particularly ischemic myocardial disease. Ursodeoxycholic acid (UDCA), already used in clinical practice for the treatment of cholelithiasis and related conditions, has proven antioxidative, anti-inflammatory, and cytoprotective effects. Therefore, the aim of this study was to investigate the cardioprotective effect of UDCA pre-treatment on isoprenaline-induced myocardial injury in rats. Male Wistar albino rats were randomized into four groups. Animals were pre-treated for 10 days with propylene glycol + saline on days 9 and 10 (control), 10 days with propylene glycol + isoprenaline on days 9 and 10 (I group), 10 days with UDCA + saline on days 9 and 10 (UDCA group), and 10 days with UDCA + isoprenaline on days 9 and 10 (UDCA + I group). UDCA pre-treatment significantly reduced values of high-sensitivity troponin I (hsTnI) and aspartate aminotransferase (AST) cardiac markers (

Indexed as

Cardiotonic AgentsIsoproterenolRats, WistarUrsodeoxycholic AcidAnimalsAntioxidantsMaleMyocardiumOxidative StressRatsThiobarbituric Acid Reactive SubstancesTroponin IAntioxidantsCardiotonic AgentsIsoproterenolThiobarbituric Acid Reactive SubstancesTroponin IUrsodeoxycholic Acidcardioprotectionisoprenaline-induced myocardial injuryoxidative stressursodeoxycholic acid

Identifiers

PMID39456147
PMCPMC11506574

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.